Nemolizumab (Biosimilar Reference Antibody) (IL31RA)
Nemolizumab (Biosimilar Reference Antibody) (IL31RA)
Nemolizumab (Biosimilar Reference Antibody) (IL31RA)-RA0381-Oursmab determined by SDS-PAGE. The purity of the protein is greater than 98%.
ELISA plate pre-coated Antigen protein, can bind Nemolizumab (Biosimilar Reference Antibody) (IL31RA)-RA0381 in a linear range of 3.91–31 ng/mL.
Nemolizumab (Biosimilar Reference Antibody) (IL31RA)

Catalog: 

RA0381

Target

IL31RA

Isotype

IgG2 - kappa

Applications

ELISA;FC;Functional Assays;IF

Reactivities

Human

Size (＄)：

100 μg-50;1 mg-210;5 mg-500;10 mg-800;25 mg-1750;50 mg-3000;100 mg-4600

Data Sheet

Material Safety Data Sheet

Certificate of Analysis

Product Description

Nemolizumab is a humanized monoclonal antibody that targets the interleukin-31 receptor A (IL-31RA), a key component of the receptor for interleukin-31 (IL-31). By binding to IL-31RA, it blocks the interaction between IL-31 and its receptor, thereby inhibiting downstream JAK/STAT signaling that drives pruritus (itch) and inflammation. IL-31 is a major pruritogenic cytokine in atopic dermatitis (eczema). Nemolizumab is approved in Japan for the treatment of pruritus associated with atopic dermatitis and is under regulatory review in other regions for the same indication. It is administered via subcutaneous injection and has shown significant efficacy in reducing itch and improving skin lesions.

Synonyms

CIM 331, CIM331, nemolizumab-ilto

CAS

1476039-58-3

Isotype

IgG2 - kappa

Host

Humanised

Target

IL31RA

Reactivity

Human

Expression System

CHO

Applications

ELISA, FC, Functional Assays, IF; Recommended dilution: FC, IF:1:200

Purity

>98% by SDS-PAGE

Concentration

Bottled at the concentration indicated on the vial.

Buffer

0.01M PBS, pH 7.4, contains no stabilizers or preservatives.

Endotoxin

<1.0 EU/mg as determined by LAL method

Conjugation

Non-conjugated

Formulation

Liquid or Lyophilized powder Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Storage

store at -20°C or -80°C. Avoid repeated freeze.

Type

Antibody

Purposes

For research use only

References 1

Nakahara T, et, al. Nemolizumab and Atopic Dermatitis: the Interaction Between Interleukin-31 and Interleukin-31 Receptor as a Potential Therapeutic Target for Pruritus in Patients With Atopic Dermatitis. 2018;5:405–14.

References 2

O Nemoto, et al. The first trial of CIM331, a humanized antihuman interleukin-31 receptor A antibody, in healthy volunteers and patients with atopic dermatitis to evaluate safety, tolerability and pharmacokinetics of a single dose in a randomized, double-blind, placebo-controlled study. Br J Dermatol. 2016 Feb;174(2):296-304.

References 3

References 4

References 5

Product Citations 1

Product Citations 2

https://link.springer.com/article/10.1007/s40521-018-0191-3
https://pubmed.ncbi.nlm.nih.gov/26409172/
https://www.oursmab.com/News/The-inflammatory-itch-cytokine-IL-31.html

Target Description

Synonyms

interleukin 31 receptor subunit alpha, interleukin 31 receptor A

Biology Area

Cytokine Receptor;Immunology

Function

The interleukin-31 receptor is a heterodimeric complex composed of IL-31 receptor A (IL-31RA) and the oncostatin M receptor beta (OSMRβ). It is expressed on neurons, keratinocytes, and immune cells. Binding of IL-31 (produced mainly by Th2 cells and eosinophils) to this receptor activates the JAK/STAT, MAPK, and PI3K pathways, leading to pruritus, epidermal barrier dysfunction, and inflammatory responses.

Additional Articles 1

The-inflammatory-itch-cytokine-IL-31

Additional Articles 2

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