Racotumomab (Biosimilar Reference Antibody) (Idiotope of anti-NeuGc-ganliosides)
Racotumomab (Biosimilar Reference Antibody) (Idiotope of anti-NeuGc-ganliosides)-RA0305-Oursmab determined by SDS-PAGE. The purity of the protein is greater than 98%.
Racotumomab (Biosimilar Reference Antibody) (Idiotope of anti-NeuGc-ganliosides)

Catalog: 

RA0305

Target

Idiotope of anti-NeuGc-ganliosides

Isotype

IgG1 - kappa

Applications

Functional Assays

Reactivities

Drug

Size ($):

100 μg-50;1 mg-210;5 mg-500;10 mg-800;25 mg-1750;50 mg-3000;100 mg-4600

Data Sheet

Material Safety Data Sheet

Certificate of Analysis

Product Description

Racotumomab is a therapeutic anti-idiotype monoclonal antibody vaccine. It mimics the structure of Neu5Gc-GM3 ganglioside, a tumor-associated antigen expressed on various cancer cells (e.g., melanoma, breast, lung). The vaccine stimulates the patient's immune system to produce antibodies against this antigen, aiming to induce an anti-tumor immune response. It has been studied primarily in advanced non-small cell lung cancer.

Synonyms

Vaxira

CAS

946832-34-4

Isotype

IgG1 - kappa

Host

Murine

Target

Idiotope of anti-NeuGc-ganliosides

Reactivity

Drug

Expression System

CHO

Applications

Functional Assays;

Purity

>98% by SDS-PAGE

Concentration

Bottled at the concentration indicated on the vial.

Buffer

0.01M PBS, pH 7.4, contains no stabilizers or preservatives.

Endotoxin

<1.0 EU/mg as determined by LAL method

Conjugation

Non-conjugated

Formulation

Liquid or Lyophilized powder Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Storage

store at -20°C or -80°C. Avoid repeated freeze.

Type

Antibody

Purposes

For research use only

References 1

Vázquez AM, et al. Racotumomab: an anti-idiotype vaccine related to N-glycolyl-containing gangliosides - preclinical and clinical data. Front Oncol. 2012 Oct 23;2:150.

References 2

Gajdosik Z. Racotumomab - a novel anti-idiotype monoclonal antibody vaccine for the treatment of cancer. Drugs Today (Barc). 2014 Apr;50(4):301-7.

References 3

References 4

References 5

Product Citations 1

Product Citations 2

https://pubmed.ncbi.nlm.nih.gov/23110257/
https://pubmed.ncbi.nlm.nih.gov/24918647/

Target Description

Synonyms

idiotope of anti-(N-glycolylneuraminic acid (NeuGc, NGNA) -gangliosides GM3) Mus musculus IgM-kappa monoclonal antibody P3

Biology Area

Tumor Antigens;Cancer Biology;Immunology

Function

Neu5Gc-GM3 ganglioside, is a sialylated glycosphingolipid overexpressed on many malignant cells but minimally present in normal human tissues. Racotumomab acts as an antigen mimic; by mimicking this tumor-associated carbohydrate antigen, it triggers a humoral immune response. This leads to the production of antibodies that recognize and bind to Neu5Gc-GM3 on cancer cells, potentially mediating antibody-dependent cytotoxicity and inhibiting tumor growth.

Additional Articles 1

Additional Articles 2

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