Rademikibart (Biosimilar Reference Antibody) (IL4R)
Rademikibart (Biosimilar Reference Antibody) (IL4R)
Rademikibart (Biosimilar Reference Antibody) (IL4R)-RA0392-Oursmab determined by SDS-PAGE. The purity of the protein is greater than 98%.
ELISA plate pre-coated Antigen protein, can bind Rademikibart (Biosimilar Reference Antibody) (IL4R)-RA0392 in a linear range of 15.63–125 ng/mL.
Rademikibart (Biosimilar Reference Antibody) (IL4R)

Catalog: 

RA0392

Target

IL4R/CD124

Isotype

IgG4 - kappa

Applications

ELISA;FC;Functional Assays;IF

Reactivities

Human

Size (＄)：

100 μg-50;1 mg-210;5 mg-500;10 mg-800;25 mg-1750;50 mg-3000;100 mg-4600

Data Sheet

Material Safety Data Sheet

Certificate of Analysis

Product Description

Rademikibart is a human monoclonal antibody designed to selectively target and neutralize interleukin-4 receptor alpha (IL-4Rα). By blocking IL-4Rα, it inhibits signaling of both IL-4 and IL-13, key cytokines driving type 2 inflammation. It is being developed for the treatment of atopic dermatitis, asthma, and other allergic or eosinophilic diseases.

Synonyms

CAS

2648260-80-2

Isotype

IgG4 - kappa

Host

Genetically human

Target

IL4R/CD124

Reactivity

Human

Expression System

CHO

Applications

ELISA, FC, Functional Assays, IF; Recommended dilution: FC, IF:1:200

Purity

>98% by SDS-PAGE

Concentration

Bottled at the concentration indicated on the vial.

Buffer

0.01M PBS, pH 7.4, contains no stabilizers or preservatives.

Endotoxin

<1.0 EU/mg as determined by LAL method

Conjugation

Non-conjugated

Formulation

Liquid or Lyophilized powder Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Storage

store at -20°C or -80°C. Avoid repeated freeze.

Type

Antibody

Purposes

For research use only

References 1

Limin Zhang, et al. Preclinical immunological characterization of rademikibart (CBP-201), a next-generation human monoclonal antibody targeting IL-4R伪, for the treatment of Th2 inflammatory diseases. Sci Rep. 2023 Jul 31;13(1):12411.

References 2

References 3

References 4

References 5

Product Citations 1

Product Citations 2

https://pubmed.ncbi.nlm.nih.gov/37524768/
https://www.oursmab.com/News/Allergic-response-regulator-IL4.html

Target Description

Synonyms

interleukin 4 receptor, IL4RA, IL-4RA, CD124

Biology Area

Cytokine Receptor;Immunology;CD Markers

Function

IL-4Rα, is a shared subunit of the type I (IL-4) and type II (IL-4/IL-13) cytokine receptors. Blocking IL-4Rα with rademikibart disrupts downstream JAK/STAT signaling, reducing the differentiation of Th2 cells, IgE production, eosinophil recruitment, and epithelial inflammation — thereby addressing the underlying pathology of type 2 inflammatory diseases.

Additional Articles 1

Allergic-response-regulator-IL4

Additional Articles 2

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