Ragifilimab (Biosimilar Reference Antibody) (TNFRSF18)
Ragifilimab (Biosimilar Reference Antibody) (TNFRSF18)
Ragifilimab (Biosimilar Reference Antibody) (TNFRSF18)-RA0760-Oursmab determined by SDS-PAGE. The purity of the protein is greater than 98%.
ELISA plate pre-coated Antigen protein, can bind Ragifilimab (Biosimilar Reference Antibody) (TNFRSF18)-RA0760 in a linear range of 31.25–500 ng/mL.
Ragifilimab (Biosimilar Reference Antibody) (TNFRSF18)

Catalog: 

RA0760

Target

TNFRSF18/CD357/GITR

Isotype

IgG1 - kappa

Applications

ELISA;FC;Functional Assays;IF

Reactivities

Human

Size (＄)：

100 μg-50;1 mg-210;5 mg-500;10 mg-800;25 mg-1750;50 mg-3000;100 mg-4600

Data Sheet

Material Safety Data Sheet

Certificate of Analysis

Product Description

Ragifilimab is an agonistic humanized IgG1 kappa monoclonal antibody targeting glucocorticoid-induced TNFR-related protein (GITR, TNFRSF18). By binding and activating GITR, it stimulates T cell effector functions, enhances proliferation, and reduces the suppressive activity of regulatory T cells (Tregs) within the tumor microenvironment. It is being developed as an immunomodulatory therapy for advanced solid tumors, aiming to boost anti-tumor immunity.

Synonyms

INCAGN-01876, INCAGN-1876

CAS

2207590-51-8

Isotype

IgG1 - kappa

Host

Humanised

Target

TNFRSF18/CD357/GITR

Reactivity

Human

Expression System

CHO

Applications

ELISA, FC, Functional Assays, IF; Recommended dilution: FC, IF:1:200

Purity

>98% by SDS-PAGE

Concentration

Bottled at the concentration indicated on the vial.

Buffer

0.01M PBS, pH 7.4, contains no stabilizers or preservatives.

Endotoxin

<1.0 EU/mg as determined by LAL method

Conjugation

Non-conjugated

Formulation

Liquid or Lyophilized powder Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Storage

store at -20°C or -80°C. Avoid repeated freeze.

Type

Antibody

Purposes

For research use only

References 1

Hernandez-Guerrero T, et al: Not Ready for Prime Time. Clin Cancer Res. 2022 Sep 15;28(18):3905-3907.

References 2

References 3

References 4

References 5

Product Citations 1

Product Citations 2

https://pubmed.ncbi.nlm.nih.gov/35834593/
https://www.oursmab.com/News/The-costimulatory-receptor-GITR.html

Target Description

Synonyms

tumor necrosis factor receptor (TNFR) superfamily member 18, activation-inducible TNFR family receptor, AITR, glucocorticoid-induced TNFR-related, GITR, CD357

Biology Area

Immune Checkpoint;Immunology;CD Markers

Function

GITR, is a co-stimulatory receptor expressed on activated T cells and constitutively on Tregs. Its activation promotes effector T cell survival and cytokine production while inhibiting Treg-mediated suppression. Ragifilimab acts as an agonist, cross-linking GITR to activate downstream NF-κB signaling, thereby reinvigorating exhausted T cells and weakening tumor-induced immune tolerance to enhance tumor clearance.

Additional Articles 1

The-costimulatory-receptor-GITR

Additional Articles 2

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