Refanezumab (Biosimilar Reference Antibody) (MAG)
Refanezumab (Biosimilar Reference Antibody) (MAG)
Refanezumab (Biosimilar Reference Antibody) (MAG)-RA0474-Oursmab determined by SDS-PAGE. The purity of the protein is greater than 98%.
ELISA plate pre-coated Antigen protein, can bind Refanezumab (Biosimilar Reference Antibody) (MAG)-RA0474 in a linear range of 3.91–31.25 ng/mL.
Refanezumab (Biosimilar Reference Antibody) (MAG)

Catalog: 

RA0474

Target

MAG

Isotype

IgG1 - kappa

Applications

ELISA;FC;Functional Assays;IF

Reactivities

Human

Size (＄)：

100 μg-50;1 mg-210;5 mg-500;10 mg-800;25 mg-1750;50 mg-3000;100 mg-4600

Data Sheet

Material Safety Data Sheet

Certificate of Analysis

Product Description

Refanezumab is a humanized IgG1 monoclonal antibody targeting myelin-associated glycoprotein (MAG). By binding to MAG, it blocks MAG-mediated inhibition of axon regeneration, aiming to promote nerve repair and functional recovery in neurological conditions such as spinal cord injury and certain neuropathies.

Synonyms

GSK249320, GSK-249320

CAS

1233953-61-1

Isotype

IgG1 - kappa

Host

Humanised

Target

MAG

Reactivity

Human

Expression System

CHO

Applications

ELISA, FC, Functional Assays, IF; Recommended dilution: FC, IF:1:200

Purity

>98% by SDS-PAGE

Concentration

Bottled at the concentration indicated on the vial.

Buffer

0.01M PBS, pH 7.4, contains no stabilizers or preservatives.

Endotoxin

<1.0 EU/mg as determined by LAL method

Conjugation

Non-conjugated

Formulation

Liquid or Lyophilized powder Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Storage

store at -20°C or -80°C. Avoid repeated freeze.

Type

Antibody

Purposes

For research use only

References 1

Diana Cash, et al. GSK249320, A Monoclonal Antibody Against the Axon Outgrowth Inhibition Molecule Myelin-Associated Glycoprotein, Improves Outcome of Rodents with Experimental Stroke. J Neurol Exp Neurosci. 2016;2(2):28-33. Epub 2016 Nov 21.

References 2

B Abila, et al. First-time-in-human study with GSK249320, a myelin-associated glycoprotein inhibitor, in healthy volunteers. Clin Pharmacol Ther. 2013 Feb;93(2):163-9.

References 3

References 4

References 5

Product Citations 1

Product Citations 2

https://pubmed.ncbi.nlm.nih.gov/28018988/
https://pubmed.ncbi.nlm.nih.gov/23267856/
https://www.oursmab.com/News/Myelin-Associated-Glycoprotein-MAG.html

Target Description

Synonyms

myelin associated glycoprotein, S-MAG, sialic acid binding Ig-like lectin 4A, SIGLEC-4A, SIGLEC4A

Biology Area

Neuroscience

Function

MAG, is a protein expressed in myelin that inhibits neurite outgrowth and axon regeneration via interactions with neuronal receptors (e.g., NgR, paired Ig-like receptor B). Refanezumab neutralizes this inhibitory signal, potentially enabling axonal regrowth and synaptic reconnection in damaged nervous tissues.

Additional Articles 1

Myelin-Associated-Glycoprotein-MAG

Additional Articles 2

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