Riliprubart (Biosimilar Reference Antibody) (C1S)
Riliprubart (Biosimilar Reference Antibody) (C1S)
Riliprubart (Biosimilar Reference Antibody) (C1S)-RA0043-Oursmab determined by SDS-PAGE. The purity of the protein is greater than 98%.
ELISA plate pre-coated Antigen protein, can bind Riliprubart (Biosimilar Reference Antibody) (C1S)-RA0043 in a linear range of 15.63–125 ng/mL.
Riliprubart (Biosimilar Reference Antibody) (C1S)

Catalog: 

RA0043

Target

C1S

Isotype

IgG4 - kappa

Applications

ELISA;FC;Functional Assays;IF

Reactivities

Human

Size (＄)：

100 μg-50;1 mg-210;5 mg-500;10 mg-800;25 mg-1750;50 mg-3000;100 mg-4600

Data Sheet

Material Safety Data Sheet

Certificate of Analysis

Product Description

Riliprubart is a humanized IgG4 kappa monoclonal antibody targeting complement component 1s (C1s). It inhibits C1s to block classical complement pathway activation, reducing inflammation and tissue damage. It is being developed for autoimmune and complement-mediated disorders such as cold agglutinin disease and lupus nephritis.

Synonyms

CAS

2756228-76-7

Isotype

IgG4 - kappa

Host

Chimeric

Target

C1S

Reactivity

Human

Expression System

CHO

Applications

ELISA, FC, Functional Assays, IF; Recommended dilution: FC, IF:1:200

Purity

>98% by SDS-PAGE

Concentration

Bottled at the concentration indicated on the vial.

Buffer

0.01M PBS, pH 7.4, contains no stabilizers or preservatives.

Endotoxin

<1.0 EU/mg as determined by LAL method

Conjugation

Non-conjugated

Formulation

Liquid or Lyophilized powder Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Storage

store at -20°C or -80°C. Avoid repeated freeze.

Type

Antibody

Purposes

For research use only

References 1

Timothy Chow, et al. First-in-human study with SAR445088: A novel selective classical complement pathway inhibitor. Clin Transl Sci. 2023 Apr;16(4):673-685.

References 2

References 3

References 4

References 5

Product Citations 1

Product Citations 2

https://pubmed.ncbi.nlm.nih.gov/36661084/
https://www.oursmab.com/News/Complement-Cascade-Initiator-C1s.html

Target Description

Synonyms

complement C1s, complement component 1, s subcomponent

Biology Area

Immunology;Innate Immunity

Function

C1s, is a serine protease within the C1 complex of the classical complement pathway. Its cleavage of C4 and C2 initiates the complement cascade. By inhibiting C1s, riliprubart prevents downstream formation of C3 convertase and the membrane attack complex, thereby controlling classical pathway-driven pathology while leaving alternative and lectin pathways largely intact.

Additional Articles 1

Complement-Cascade-Initiator-C1s

Additional Articles 2

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