Rilotumumab (Biosimilar Reference Antibody) (HGF)
Rilotumumab (Biosimilar Reference Antibody) (HGF)
Rilotumumab (Biosimilar Reference Antibody) (HGF)-RA0290-Oursmab determined by SDS-PAGE. The purity of the protein is greater than 98%.
ELISA plate pre-coated Antigen protein, can bind Rilotumumab (Biosimilar Reference Antibody) (HGF)-RA0290 in a linear range of 15.63–125 ng/mL.
Rilotumumab (Biosimilar Reference Antibody) (HGF)

Catalog: 

RA0290

Target

HGF/SF

Isotype

IgG2 - kappa

Applications

ELISA;FC;Functional Assays;IF

Reactivities

Human

Size (＄)：

100 μg-50;1 mg-210;5 mg-500;10 mg-800;25 mg-1750;50 mg-3000;100 mg-4600

Data Sheet

Material Safety Data Sheet

Certificate of Analysis

Product Description

Rilotumumab is a fully human monoclonal antibody targeting hepatocyte growth factor (HGF). It binds to HGF to prevent its interaction with the c-Met receptor, thereby inhibiting the HGF/c-Met signaling pathway involved in tumor growth, angiogenesis, and metastasis. It was investigated for the treatment of advanced solid tumors such as gastric cancer and glioblastoma.

Synonyms

AMG 102, AMG102

CAS

872514-65-3

Isotype

IgG2 - kappa

Host

Genetically human

Target

HGF/SF

Reactivity

Human

Expression System

CHO

Applications

ELISA, FC, Functional Assays, IF; Recommended dilution: FC, IF:1:200

Purity

>98% by SDS-PAGE

Concentration

Bottled at the concentration indicated on the vial.

Buffer

0.01M PBS, pH 7.4, contains no stabilizers or preservatives.

Endotoxin

<1.0 EU/mg as determined by LAL method

Conjugation

Non-conjugated

Formulation

Liquid or Lyophilized powder Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Storage

store at -20°C or -80°C. Avoid repeated freeze.

Type

Antibody

Purposes

For research use only

References 1

Ryan CJ, et al. Targeted MET inhibition in castration-resistant prostate cancer: a randomized phase II study and biomarker analysis with rilotumumab plus mitoxantrone and prednisone. Clin Cancer Res. 2013 Jan 1;19(1):215-24.

References 2

Greenall SA, et al. EGFRvIII-mediated transactivation of receptor tyrosine kinases in glioma: mechanism and therapeutic implications. Oncogene. 2015 Oct 8;34(41):5277-87.

References 3

References 4

References 5

Product Citations 1

Product Citations 2

https://pubmed.ncbi.nlm.nih.gov/23136195/
https://pubmed.ncbi.nlm.nih.gov/25659577/
https://www.oursmab.com/News/Hepatocyte-growth-factor-HGF.html

Target Description

Synonyms

hepatocyte growth factor, scatter factor, SF, hepatopoeitin A

Biology Area

Cancer Biology;Tumor Antigens

Function

HGF, is a ligand for the receptor tyrosine kinase c-Met. HGF/c-Met signaling promotes cell proliferation, survival, migration, and invasion. By neutralizing HGF, rilotumumab aims to suppress tumor progression and metastasis, particularly in cancers with dysregulated c-Met pathway activity.

Additional Articles 1

Hepatocyte-growth-factor-HGF

Additional Articles 2

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