Rolistobart (Biosimilar Reference Antibody) (LILRB4)
Rolistobart (Biosimilar Reference Antibody) (LILRB4)
Rolistobart (Biosimilar Reference Antibody) (LILRB4)-RA0466-Oursmab determined by SDS-PAGE. The purity of the protein is greater than 98%.
ELISA plate pre-coated Antigen protein, can bind Rolistobart (Biosimilar Reference Antibody) (LILRB4)-RA0466 in a linear range of 15.63–125 ng/mL.
Rolistobart (Biosimilar Reference Antibody) (LILRB4)

Catalog: 

RA0466

Target

LILRB4/CD85K

Isotype

IgG4 - kappa

Applications

ELISA;FC;Functional Assays;IF

Reactivities

Human

Size (＄)：

100 μg-50;1 mg-210;5 mg-500;10 mg-800;25 mg-1750;50 mg-3000;100 mg-4600

Data Sheet

Material Safety Data Sheet

Certificate of Analysis

Product Description

Rolistobart is a humanized IgG4 kappa monoclonal antibody targeting leukocyte immunoglobulin-like receptor subfamily B member 4 (LILRB4, also known as CD85k or ILT3). It blocks LILRB4, an inhibitory receptor expressed on immune cells, to enhance anti-tumor immunity. It is being developed for cancer immunotherapy, particularly in myeloid malignancies and solid tumors.

Synonyms

CAS

2723442-10-0

Isotype

IgG4 - kappa

Host

Humanised

Target

LILRB4/CD85K

Reactivity

Human

Expression System

CHO

Applications

ELISA, FC, Functional Assays, IF; Recommended dilution: FC, IF:1:200

Purity

>98% by SDS-PAGE

Concentration

Bottled at the concentration indicated on the vial.

Buffer

0.01M PBS, pH 7.4, contains no stabilizers or preservatives.

Endotoxin

<1.0 EU/mg as determined by LAL method

Conjugation

Non-conjugated

Formulation

Liquid or Lyophilized powder Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Storage

store at -20°C or -80°C. Avoid repeated freeze.

Type

Antibody

Purposes

For research use only

References 1

International Nonproprietary Names for Pharmaceutical Substances (INN). WHO Drug Information, Vol. 36, No. 4, 2022.

References 2

References 3

References 4

References 5

Product Citations 1

Product Citations 2

https://cdn.who.int/media/docs/default-source/international-nonproprietary-names-(inn)/pl128.pdf?sfvrsn=889fe54b_3&download=true

Target Description

Synonyms

leukocyte immunoglobulin like receptor B4, ILT3, LIR-5, CD85k

Biology Area

Immune Checkpoint;Immunology;CD Markers

Function

LILRB4 (CD85k), is an immune checkpoint that suppresses T cell activation and promotes immune tolerance. By inhibiting LILRB4, rolistobart aims to reverse immunosuppression in the tumor microenvironment, reactivating T cells and potentially improving tumor clearance in cancers with high myeloid-derived suppressor cell (MDSC) or monocytic infiltration.

Additional Articles 1

Additional Articles 2

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