Rontalizumab (Biosimilar Reference Antibody) (IFNA1)
Rontalizumab (Biosimilar Reference Antibody) (IFNA1)
Rontalizumab (Biosimilar Reference Antibody) (IFNA1)-RA0307-Oursmab determined by SDS-PAGE. The purity of the protein is greater than 98%.
ELISA plate pre-coated Antigen protein, can bind Rontalizumab (Biosimilar Reference Antibody) (IFNA1)-RA0307 in a linear range of 31.25–125 ng/mL.
Rontalizumab (Biosimilar Reference Antibody) (IFNA1)

Catalog: 

RA0307

Target

IFNA1

Isotype

IgG1 - kappa

Applications

ELISA;FC;Functional Assays;IF

Reactivities

Human

Size (＄)：

100 μg-50;1 mg-210;5 mg-500;10 mg-800;25 mg-1750;50 mg-3000;100 mg-4600

Data Sheet

Material Safety Data Sheet

Certificate of Analysis

Product Description

Rontalizumab is a humanized monoclonal antibody targeting interferon-alpha (IFN-α). It binds to and neutralizes multiple subtypes of IFN-α, a key cytokine in the pathogenesis of systemic lupus erythematosus (SLE). It was developed to reduce disease activity by inhibiting IFN-α-mediated immune activation and inflammation in SLE patients with an elevated interferon signature.

Synonyms

RhuMAB IFNalpha

CAS

948570-30-7

Isotype

IgG1 - kappa

Host

Humanised

Target

IFNA1

Reactivity

Human

Expression System

CHO

Applications

ELISA, FC, Functional Assays, IF; Recommended dilution: FC, IF:1:200

Purity

>98% by SDS-PAGE

Concentration

Bottled at the concentration indicated on the vial.

Buffer

0.01M PBS, pH 7.4, contains no stabilizers or preservatives.

Endotoxin

<1.0 EU/mg as determined by LAL method

Conjugation

Non-conjugated

Formulation

Liquid or Lyophilized powder Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Storage

store at -20°C or -80°C. Avoid repeated freeze.

Type

Antibody

Purposes

For research use only

References 1

McBride JM, et al. Safety and pharmacodynamics of rontalizumab in patients with systemic lupus erythematosus: results of a phase I, placebo-controlled, double-blind, dose-escalation study. Arthritis Rheum. 2012 Nov;64(11):3666-76.

References 2

References 3

References 4

References 5

Product Citations 1

Product Citations 2

https://pubmed.ncbi.nlm.nih.gov/22833362/
https://www.oursmab.com/News/Type-I-interferon-targets-IFNA1-and-IFNB.html

Target Description

Synonyms

interferon alpha 1, IFN-alpha, IFN alpha 1/13, IFN 13

Biology Area

Cytokine and Chemokine;Immunology

Function

IFN-α, is a type I interferon that promotes dendritic cell maturation, B cell activation, and autoantibody production. By blocking IFN-α, rontalizumab aims to dampen the chronic interferon-driven inflammation characteristic of SLE, potentially improving clinical outcomes in patients with high interferon pathway activity.

Additional Articles 1

Type-I-interferon-targets-IFNA1-and-IFNB

Additional Articles 2

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