Rosmantuzumab (Biosimilar Reference Antibody) (RSPO3)
Rosmantuzumab (Biosimilar Reference Antibody) (RSPO3)
Rosmantuzumab (Biosimilar Reference Antibody) (RSPO3)-RA0639-Oursmab determined by SDS-PAGE. The purity of the protein is greater than 98%.
ELISA plate pre-coated Antigen protein, can bind Rosmantuzumab (Biosimilar Reference Antibody) (RSPO3)-RA0639 in a linear range of 15.63–125 ng/mL.
Rosmantuzumab (Biosimilar Reference Antibody) (RSPO3)

Catalog: 

RA0639

Target

RSPO3

Isotype

IgG1 - kappa

Applications

ELISA;FC;Functional Assays;IF

Reactivities

Human

Size (＄)：

100 μg-50;1 mg-210;5 mg-500;10 mg-800;25 mg-1750;50 mg-3000;100 mg-4600

Data Sheet

Material Safety Data Sheet

Certificate of Analysis

Product Description

Rosmantuzumab is a humanized IgG1 kappa monoclonal antibody targeting R-spondin 3 (RSPO3). It neutralizes RSPO3, a protein that enhances Wnt/β-catenin signaling by binding to LGR receptors and stabilizing RNF43/ZNRF3. It is being developed for the treatment of solid tumors, particularly colorectal and pancreatic cancers where aberrant RSPO3-Wnt signaling drives tumor growth.

Synonyms

OMP-131R10

CAS

1684393-04-1

Isotype

IgG1 - kappa

Host

Humanised

Target

RSPO3

Reactivity

Human

Expression System

CHO

Applications

ELISA, FC, Functional Assays, IF; Recommended dilution: FC, IF:1:200

Purity

>98% by SDS-PAGE

Concentration

Bottled at the concentration indicated on the vial.

Buffer

0.01M PBS, pH 7.4, contains no stabilizers or preservatives.

Endotoxin

<1.0 EU/mg as determined by LAL method

Conjugation

Non-conjugated

Formulation

Liquid or Lyophilized powder Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Storage

store at -20°C or -80°C. Avoid repeated freeze.

Type

Antibody

Purposes

For research use only

References 1

Zhang M, et al. Targeting the Wnt signaling pathway through R-spondin 3 identifies an anti-fibrosis treatment strategy for multiple organs. PLoS One. 2020 Mar 11;15(3):e0229445.

References 2

References 3

References 4

References 5

Product Citations 1

Product Citations 2

https://pubmed.ncbi.nlm.nih.gov/32160239/
https://www.oursmab.com/News/The-key-regulator-of-angiogenesis-RSPO3.html

Target Description

Synonyms

R-spondin 3, "R-spondin 3 homolog (Xenopus laevis)", "thrombospondin, type I, domain containing 2", THSD2, FLJ14440

Biology Area

Cancer Biology;Developmental Signaling

Function

RSPO3, amplifies Wnt pathway activity, promoting cancer stem cell renewal and tumor proliferation. By inhibiting RSPO3, rosmantuzumab suppresses Wnt signaling, aiming to reduce tumor growth and overcome resistance in RSPO3-dependent cancers. It is often studied in tumors with RSPO gene fusions or overexpression.

Additional Articles 1

The-key-regulator-of-angiogenesis-RSPO3

Additional Articles 2

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