Ruplizumab (Biosimilar Reference Antibody) (CD40LG)
Ruplizumab (Biosimilar Reference Antibody) (CD40LG)
Ruplizumab (Biosimilar Reference Antibody) (CD40LG)-RA0117-Oursmab determined by SDS-PAGE. The purity of the protein is greater than 98%.
ELISA plate pre-coated Antigen protein, can bind Ruplizumab biosimilar in a linear range of 3.91-125 ng/mL.
Ruplizumab (Biosimilar Reference Antibody) (CD40LG)

Catalog: 

RA0117

Target

CD40LG/CD154

Isotype

IgG1 - kappa

Applications

ELISA;FC;Functional Assays;IF

Reactivities

Human

Size (＄)：

100 μg-50;1 mg-210;5 mg-500;10 mg-800;25 mg-1750;50 mg-3000;100 mg-4600

Data Sheet

Material Safety Data Sheet

Certificate of Analysis

Product Description

Ruplizumab is a humanized monoclonal antibody targeting CD40 ligand (CD40L, also known as CD154). It binds to CD40L on activated T cells, blocking its interaction with CD40 on antigen-presenting cells (e.g., B cells, dendritic cells). This inhibition suppresses T cell-dependent B cell activation, antibody production, and inflammatory responses. It was historically investigated for the treatment of autoimmune diseases such as systemic lupus erythematosus (SLE) and prevention of transplant rejection.

Synonyms

BG-9588, hu5c8

CAS

220651-94-5

Isotype

IgG1 - kappa

Host

Humanised

Target

CD40LG/CD154

Reactivity

Human

Expression System

CHO

Applications

ELISA, FC, Functional Assays, IF; Recommended dilution: FC, IF:1:200

Purity

>98% by SDS-PAGE

Concentration

Bottled at the concentration indicated on the vial.

Buffer

0.01M PBS, pH 7.4, contains no stabilizers or preservatives.

Endotoxin

<1.0 EU/mg as determined by LAL method

Conjugation

Non-conjugated

Formulation

Liquid or Lyophilized powder Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Storage

store at -20°C or -80°C. Avoid repeated freeze.

Type

Antibody

Purposes

For research use only

References 1

Chris Chamberlain, et al. Repeated administration of dapirolizumab pegol in a randomised phase I study is well tolerated and accompanied by improvements in several composite measures of systemic lupus erythematosus disease activity and changes in whole blood transcriptomic profiles. Ann Rheum Dis. 2017 Nov;76(11):1837-1844.

References 2

Law C L, et al. Therapeutic interventions targeting CD40L (CD154) and CD40: the opportunities and challenges. Therapeutic targets of the TNF superfamily, 2009: 8-36.

References 3

References 4

References 5

Product Citations 1

Product Citations 2

https://pubmed.ncbi.nlm.nih.gov/28780512/
https://link.springer.com/book/10.1007/978-0-387-89520-8#page=24%23page=24
https://www.oursmab.com/News/CD40-ligand-CD154.html

Target Description

Synonyms

CD40 ligand, CD40L, tumor necrosis factor ligand superfamily member 5, TNFSF5, tumor necrosis factor related activation protein, TRAP, CD154

Biology Area

Immunology;Immune Checkpoint;CD Markers

Function

CD40L, is a co-stimulatory molecule critical for immune activation. By blocking CD40L, ruplizumab aimed to reduce autoantibody generation and inflammatory tissue damage in autoimmune disorders, though clinical development faced challenges due to thromboembolic side effects observed in early trials.

Additional Articles 1

CD40-ligand-CD154

Additional Articles 2

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