Sifalimumab (Biosimilar Reference Antibody) (IFNA1)
Sifalimumab (Biosimilar Reference Antibody) (IFNA1)
Sifalimumab (Biosimilar Reference Antibody) (IFNA1)-RA0308-Oursmab determined by SDS-PAGE. The purity of the protein is greater than 98%.
ELISA plate pre-coated Antigen protein, can bind Sifalimumab (Biosimilar Reference Antibody) (IFNA1)-RA0308 in a linear range of 15.63–125 ng/mL.
Sifalimumab (Biosimilar Reference Antibody) (IFNA1)

Catalog: 

RA0308

Target

IFNA1

Isotype

IgG1 - kappa

Applications

ELISA;FC;Functional Assays;IF

Reactivities

Human

Size (＄)：

100 μg-50;1 mg-210;5 mg-500;10 mg-800;25 mg-1750;50 mg-3000;100 mg-4600

Data Sheet

Material Safety Data Sheet

Certificate of Analysis

Product Description

Sifalimumab is a fully human monoclonal antibody targeting interferon-alpha (IFN-α), a key cytokine in systemic lupus erythematosus (SLE) pathogenesis. It neutralizes multiple IFN-α subtypes, aiming to reduce the "interferon signature" and dampen autoimmune activity. It was investigated in clinical trials for moderate-to-severe SLE.

Synonyms

MDX-1103, MEDI-545

CAS

1006877-41-3

Isotype

IgG1 - kappa

Host

Genetically human

Target

IFNA1

Reactivity

Human

Expression System

CHO

Applications

ELISA, FC, Functional Assays, IF; Recommended dilution: FC, IF:1:200

Purity

>98% by SDS-PAGE

Concentration

Bottled at the concentration indicated on the vial.

Buffer

0.01M PBS, pH 7.4, contains no stabilizers or preservatives.

Endotoxin

<1.0 EU/mg as determined by LAL method

Conjugation

Non-conjugated

Formulation

Liquid or Lyophilized powder Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Storage

store at -20°C or -80°C. Avoid repeated freeze.

Type

Antibody

Purposes

For research use only

References 1

Merrill JT, et al. Safety profile and clinical activity of sifalimumab, a fully human anti-interferon 伪 monoclonal antibody, in systemic lupus erythematosus: a phase I, multicentre, double-blind randomised study. Ann Rheum Dis. 2011 Nov;70(11):1905-13.聽

References 2

La Maestra S, et al. Brain microglia activation induced by intracranial administration of oligonucleotides and its pharmacological modulation. Drug Deliv Transl Res. 2018 Oct;8(5):1345-1354.

References 3

References 4

References 5

Product Citations 1

Product Citations 2

https://pubmed.ncbi.nlm.nih.gov/21798883/
https://pubmed.ncbi.nlm.nih.gov/29869293/

Target Description

Synonyms

interferon alpha 1, IFN-alpha, IFN alpha 1/13, IFN 13

Biology Area

Cytokine and Chemokine;Immunology

Function

IFN-α, drives dendritic cell activation, autoreactive B cell survival, and tissue inflammation in SLE. By blocking IFN-α, sifalimumab sought to decrease disease flares, lower autoantibody levels, and improve clinical outcomes, particularly in patients with high baseline interferon signaling.

Additional Articles 1

Additional Articles 2

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