Simtuzumab (Biosimilar Reference Antibody) (LOXL2)
Simtuzumab (Biosimilar Reference Antibody) (LOXL2)
Simtuzumab (Biosimilar Reference Antibody) (LOXL2)-RA0468-Oursmab determined by SDS-PAGE. The purity of the protein is greater than 98%.
ELISA plate pre-coated Antigen protein, can bind Simtuzumab (Biosimilar Reference Antibody) (LOXL2)-RA0468 in a linear range of 15.63–125 ng/mL.
Simtuzumab (Biosimilar Reference Antibody) (LOXL2)

Catalog: 

RA0468

Target

LOXL2

Isotype

IgG4 - kappa

Applications

ELISA;FC;Functional Assays;IF

Reactivities

Human

Size (＄)：

100 μg-50;1 mg-210;5 mg-500;10 mg-800;25 mg-1750;50 mg-3000;100 mg-4600

Data Sheet

Material Safety Data Sheet

Certificate of Analysis

Product Description

Simtuzumab is a humanized monoclonal antibody targeting lysyl oxidase-like 2 (LOXL2), an enzyme involved in collagen cross-linking and fibrosis. It inhibits LOXL2 to reduce extracellular matrix stiffness and fibrogenesis. It was investigated for the treatment of fibrotic diseases such as idiopathic pulmonary fibrosis (IPF), nonalcoholic steatohepatitis (NASH), and liver fibrosis.

Synonyms

AB0024, GS-6624

CAS

1318075-13-6

Isotype

IgG4 - kappa

Host

Humanised

Target

LOXL2

Reactivity

Human

Expression System

CHO

Applications

ELISA, FC, Functional Assays, IF; Recommended dilution: FC, IF:1:200

Purity

>98% by SDS-PAGE

Concentration

Bottled at the concentration indicated on the vial.

Buffer

0.01M PBS, pH 7.4, contains no stabilizers or preservatives.

Endotoxin

<1.0 EU/mg as determined by LAL method

Conjugation

Non-conjugated

Formulation

Liquid or Lyophilized powder Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Storage

store at -20°C or -80°C. Avoid repeated freeze.

Type

Antibody

Purposes

For research use only

References 1

Wei Chen, et al. Lysyl Oxidase (LOX) Family Members: Rationale and Their Potential as Therapeutic Targets for Liver Fibrosis. Hepatology. 2020 Aug;72(2):729-741.

References 2

References 3

References 4

References 5

Product Citations 1

Product Citations 2

https://pubmed.ncbi.nlm.nih.gov/32176358/
https://www.oursmab.com/News/Lysyl-oxidase-like-protein-LOXL2.html

Target Description

Synonyms

lysyl oxidase-like 2

Biology Area

Fibrosis;Cancer Biology

Function

LOXL2, catalyzes the cross-linking of collagen and elastin fibers, contributing to tissue stiffening and progression of fibrosis. By blocking LOXL2, simtuzumab aimed to slow or reverse fibrotic remodeling, though clinical trials in IPF and NASH did not demonstrate significant efficacy, leading to discontinuation of development.

Additional Articles 1

Lysyl-oxidase-like-protein-LOXL2

Additional Articles 2

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