Sirukumab (Biosimilar Reference Antibody) (IL6)
Sirukumab (Biosimilar Reference Antibody) (IL6)
Sirukumab (Biosimilar Reference Antibody) (IL6)-RA0402-Oursmab determined by SDS-PAGE. The purity of the protein is greater than 98%.
ELISA plate pre-coated Antigen protein, can bind Sirukumab (Biosimilar Reference Antibody) (IL6)-RA0402 in a linear range of 3.91–125 ng/mL.
Sirukumab (Biosimilar Reference Antibody) (IL6)

Catalog: 

RA0402

Target

IL6

Isotype

IgG1 - kappa

Applications

ELISA;FC;Functional Assays;IF

Reactivities

Human

Size (＄)：

100 μg-50;1 mg-210;5 mg-500;10 mg-800;25 mg-1750;50 mg-3000;100 mg-4600

Data Sheet

Material Safety Data Sheet

Certificate of Analysis

Product Description

Sirukumab is a human monoclonal antibody targeting interleukin-6 (IL-6), a pro-inflammatory cytokine. It binds to soluble IL-6 with high affinity, preventing its interaction with both soluble and membrane-bound IL-6 receptors. It was investigated for the treatment of rheumatoid arthritis (RA), but development was discontinued after regulatory reviews highlighted safety concerns, including increased risk of serious infections and mortality.

Synonyms

CNTO 136

CAS

1194585-53-9

Isotype

IgG1 - kappa

Host

Genetically human

Target

IL6

Reactivity

Human

Expression System

CHO

Applications

ELISA, FC, Functional Assays, IF; Recommended dilution: FC, IF:1:200

Purity

>98% by SDS-PAGE

Concentration

Bottled at the concentration indicated on the vial.

Buffer

0.01M PBS, pH 7.4, contains no stabilizers or preservatives.

Endotoxin

<1.0 EU/mg as determined by LAL method

Conjugation

Non-conjugated

Formulation

Liquid or Lyophilized powder Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Storage

store at -20°C or -80°C. Avoid repeated freeze.

Type

Antibody

Purposes

For research use only

References 1

Brad H Rovin, et al. A Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of Treatment With Sirukumab (CNTO 136) in Patients With Active Lupus Nephritis. Arthritis Rheumatol. 2016 Sep;68(9):2174-83.

References 2

Bartoli F, et al. Sirukumab for the treatment of rheumatoid arthritis: update on sirukumab, 2018[J]. Expert Review of Clinical Immunology, 2018, 14(7): 539-547.

References 3

References 4

References 5

Product Citations 1

Product Citations 2

https://pubmed.ncbi.nlm.nih.gov/27110697/
https://pubmed.ncbi.nlm.nih.gov/29925278/
https://www.oursmab.com/News/polygenic-proinflammatory-cytokine-IL6.html

Target Description

Synonyms

interleukin 6, IL-6

Biology Area

Cytokine and Chemokine;Immunology

Function

Interleukin-6 (IL-6), a pleiotropic pro-inflammatory cytokine. In the context of transplant rejection, IL-6 plays a central and multifaceted role in promoting both adaptive and innate immune responses that damage the graft. It drives the differentiation and activity of antibody-producing plasma cells and memory B cells, which generate donor-specific antibodies (DSAs) that attack the transplant. Simultaneously, IL-6 promotes T-cell activation and inhibits the development of regulatory T cells (Tregs).

Additional Articles 1

polygenic-proinflammatory-cytokine-IL6

Additional Articles 2

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