Solrikitug (Biosimilar Reference Antibody) (CRLF2)
Solrikitug (Biosimilar Reference Antibody) (CRLF2)
Solrikitug (Biosimilar Reference Antibody) (CRLF2)-RA0148-Oursmab determined by SDS-PAGE. The purity of the protein is greater than 98%.
ELISA plate pre-coated Antigen protein, can bind Solrikitug (Biosimilar Reference Antibody) (CRLF2)-RA0148 in a linear range of 3.91–125 ng/mL.
Solrikitug (Biosimilar Reference Antibody) (CRLF2)

Catalog: 

RA0148

Target

CRLF2

Isotype

IgG1 - kappa

Applications

ELISA;FC;Functional Assays;IF

Reactivities

Human

Size (＄)：

100 μg-50;1 mg-210;5 mg-500;10 mg-800;25 mg-1750;50 mg-3000;100 mg-4600

Data Sheet

Material Safety Data Sheet

Certificate of Analysis

Product Description

Solrikitug is a humanized IgG1 kappa monoclonal antibody targeting cytokine receptor-like factor 2 (CRLF2), a subunit of the thymic stromal lymphopoietin (TSLP) receptor complex. It binds to CRLF2 to block TSLP-mediated signaling, thereby inhibiting the activation of downstream inflammatory pathways involved in type 2 immunity. It is being developed for the treatment of allergic and eosinophilic diseases, such as severe asthma and atopic dermatitis.

Synonyms

CAS

2768721-24-8

Isotype

IgG1 - kappa

Host

Humanised

Target

CRLF2

Reactivity

Human

Expression System

CHO

Applications

ELISA, FC, Functional Assays, IF; Recommended dilution: FC, IF:1:200

Purity

>98% by SDS-PAGE

Concentration

Bottled at the concentration indicated on the vial.

Buffer

0.01M PBS, pH 7.4, contains no stabilizers or preservatives.

Endotoxin

<1.0 EU/mg as determined by LAL method

Conjugation

Non-conjugated

Formulation

Liquid or Lyophilized powder Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Storage

store at -20°C or -80°C. Avoid repeated freeze.

Type

Antibody

Purposes

For research use only

References 1

Solrikitug

References 2

References 3

References 4

References 5

Product Citations 1

Product Citations 2

https://www.imgt.org/mAb-DB/mAbcard?AbId=1511
https://www.oursmab.com/News/Cytokine-receptor-like-factor-2.html

Target Description

Synonyms

cytokine receptor like factor 2

Biology Area

Cancer Biology;Cytokine Receptor

Function

CRLF2, pairs with the IL-7Rα chain to form the functional TSLP receptor. TSLP signaling promotes dendritic cell maturation, Th2 cell differentiation, and eosinophil recruitment. Solrikitug's blockade of CRLF2 disrupts this cascade, reducing airway inflammation, IgE production, and tissue damage in TSLP-driven disorders, offering a targeted approach for patients with uncontrolled type 2 inflammation.

Additional Articles 1

Cytokine-receptor-like-factor-2

Additional Articles 2

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