Tezepelumab (Biosimilar Reference Antibody) (TSLP)
Tezepelumab (Biosimilar Reference Antibody) (TSLP)
Tezepelumab (Biosimilar Reference Antibody) (TSLP)-RA0804-Oursmab determined by SDS-PAGE. The purity of the protein is greater than 98%.
ELISA plate pre-coated Antigen protein, can bind Tezepelumab (Biosimilar Reference Antibody) (TSLP)-RA0804 in a linear range of 15.63–125 ng/mL.
Tezepelumab (Biosimilar Reference Antibody) (TSLP)

Catalog: 

RA0804

Target

TSLP

Isotype

IgG2 - lambda

Applications

ELISA;FC;Functional Assays;IF

Reactivities

Human

Size (＄)：

100 μg-50;1 mg-210;5 mg-500;10 mg-800;25 mg-1750;50 mg-3000;100 mg-4600

Data Sheet

Material Safety Data Sheet

Certificate of Analysis

Product Description

Tezepelumab is a fully human monoclonal antibody targeting thymic stromal lymphopoietin (TSLP), an epithelial-derived cytokine that initiates type 2 immune responses. It binds to TSLP, preventing its interaction with the TSLP receptor complex, thereby blocking downstream inflammatory pathways. It is approved for the treatment of severe asthma, particularly in patients with uncontrolled disease regardless of eosinophil levels.

Synonyms

MEDI9929, AMG 157, MEDI-9929, AMG-157

CAS

1572943-04-4

Isotype

IgG2 - lambda

Host

Genetically human

Target

TSLP

Reactivity

Human

Expression System

CHO

Applications

ELISA, FC, Functional Assays, IF; Recommended dilution: FC, IF:1:200

Purity

>98% by SDS-PAGE

Concentration

Bottled at the concentration indicated on the vial.

Buffer

0.01M PBS, pH 7.4, contains no stabilizers or preservatives.

Endotoxin

<1.0 EU/mg as determined by LAL method

Conjugation

Non-conjugated

Formulation

Liquid or Lyophilized powder Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Storage

store at -20°C or -80°C. Avoid repeated freeze.

Type

Antibody

Purposes

For research use only

References 1

Menzies-Gow A, et, al. Tezepelumab in Adults and Adolescents with Severe, Uncontrolled Asthma. N Engl J Med. 2021 May 13;384(19):1800-1809.

References 2

References 3

References 4

References 5

Product Citations 1

Product Citations 2

https://pubmed.ncbi.nlm.nih.gov/33979488/
https://www.oursmab.com/News/Thymic-stromal-lymphopoietin-TSLP.html

Target Description

Synonyms

thymic stromal lymphopoietin

Biology Area

Cytokine and Chemokine;Immunology

Function

TSLP, is a key upstream regulator of multiple inflammatory cascades (including IL-4, IL-5, IL-13, and IgE). Tezepelumab’s inhibition of TSLP reduces airway inflammation, exacerbations, and improves lung function. Its broad mechanism addresses both eosinophilic and non-eosinophilic asthma phenotypes, offering a therapeutic option for a wide range of severe asthma patients.

Additional Articles 1

Thymic-stromal-lymphopoietin-TSLP

Additional Articles 2

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