Tifcemalimab (Biosimilar Reference Antibody) (BTLA)
Tifcemalimab (Biosimilar Reference Antibody) (BTLA)
Tifcemalimab (Biosimilar Reference Antibody) (BTLA)-RA0040-Oursmab determined by SDS-PAGE. The purity of the protein is greater than 98%.
ELISA plate pre-coated Antigen protein, can bind Tifcemalimab (Biosimilar Reference Antibody) (BTLA)-RA0040 in a linear range of 15.63–125 ng/mL.
Tifcemalimab (Biosimilar Reference Antibody) (BTLA)

Catalog: 

RA0040

Target

BTLA/CD272

Isotype

IgG4 - kappa

Applications

ELISA;FC;Functional Assays;IF

Reactivities

Human

Size (＄)：

100 μg-50;1 mg-210;5 mg-500;10 mg-800;25 mg-1750;50 mg-3000;100 mg-4600

Data Sheet

Material Safety Data Sheet

Certificate of Analysis

Product Description

Tifcemalimab (TAB004/JS004) is a humanized IgG4 kappa monoclonal antibody targeting B- and T-lymphocyte attenuator (BTLA), an inhibitory immune checkpoint receptor expressed on T cells, B cells, and dendritic cells. It binds to BTLA to block its interaction with the ligand herpesvirus entry mediator (HVEM), thereby reversing immune suppression and enhancing anti-tumor immunity. It is being developed for cancer immunotherapy, often in combination with PD-1 inhibitors, for the treatment of advanced solid tumors.

Synonyms

JS004

CAS

2236068-83-8

Isotype

IgG4 - kappa

Host

Chimeric

Target

BTLA/CD272

Reactivity

Human

Expression System

CHO

Applications

ELISA, FC, Functional Assays, IF; Recommended dilution: FC, IF:1:200

Purity

>98% by SDS-PAGE

Concentration

Bottled at the concentration indicated on the vial.

Buffer

0.01M PBS, pH 7.4, contains no stabilizers or preservatives.

Endotoxin

<1.0 EU/mg as determined by LAL method

Conjugation

Non-conjugated

Formulation

Liquid or Lyophilized powder Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Storage

store at -20°C or -80°C. Avoid repeated freeze.

Type

Antibody

Purposes

For research use only

References 1

Jun Ma, et al. Phase I Study of the Anti-Btla Antibody Tifcemalimab As a Single Agent or in Combination with Toripalimab in Relapsed/Refractory Lymphomas. Blood (2022) 140 (Supplement 1): 3716–3717.

References 2

D. Lv, et al. Tifcemalimab combined with toripalimab and docetaxel as 2nd line treatment for immunotherapy-treated squamous cell non-small cell lung cancer (Sq-NSCLC) patients: A phase Ib/II study - Annals of Oncology. Volume 35, Supplement 4S1645December 2024.

References 3

References 4

References 5

Product Citations 1

Product Citations 2

https://ashpublications.org/blood/article/140/Supplement%201/3716/490831/Phase-I-Study-of-the-Anti-Btla-Antibody
https://www.annalsofoncology.org/article/S0923-7534(24)04733-1/fulltext
https://www.oursmab.com/News/B-and-T-lymphocyte-attenuator-BTLA.html

Target Description

Synonyms

B and T lymphocyte associated, BTLA1, CD272

Biology Area

Immune Checkpoint;Immunology;CD Markers

Function

BTLA, transmits inhibitory signals that dampen T cell activation and promote immune tolerance in the tumor microenvironment. Tifcemalimab's blockade of BTLA-HVEM interaction aims to restore T cell function, increase cytokine production, and overcome resistance to existing checkpoint therapies.

Additional Articles 1

B-and-T-lymphocyte-attenuator-BTLA

Additional Articles 2

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