Tovetumab (Biosimilar Reference Antibody) (PDGFRA)
Tovetumab (Biosimilar Reference Antibody) (PDGFRA)
Tovetumab (Biosimilar Reference Antibody) (PDGFRA)-RA0591-Oursmab determined by SDS-PAGE. The purity of the protein is greater than 98%.
ELISA plate pre-coated Antigen protein, can bind Tovetumab (Biosimilar Reference Antibody) (PDGFRA)-RA0591 in a linear range of 15.63–125 ng/mL.
Tovetumab (Biosimilar Reference Antibody) (PDGFRA)

Catalog: 

RA0591

Target

PDGFRA/CD140A

Isotype

IgG2 - kappa

Applications

ELISA;FC;Functional Assays;IF

Reactivities

Human

Size (＄)：

100 μg-50;1 mg-210;5 mg-500;10 mg-800;25 mg-1750;50 mg-3000;100 mg-4600

Data Sheet

Material Safety Data Sheet

Certificate of Analysis

Product Description

Tovetumab is a veterinary IgG2 kappa monoclonal antibody targeting platelet-derived growth factor receptor alpha (PDGFRα/CD140a). It binds to PDGFRα on cell surfaces, blocking ligand-induced activation and downstream signaling pathways involved in cell proliferation and fibrosis. It is being developed for the treatment of fibrotic or hyperproliferative conditions in animals, such as canine or feline chronic kidney disease or certain tumors.

Synonyms

MEDI-575

CAS

1243266-04-7

Isotype

IgG2 - kappa

Host

Genetically human

Target

PDGFRA/CD140A

Reactivity

Human

Expression System

CHO

Applications

ELISA, FC, Functional Assays, IF; Recommended dilution: FC, IF:1:200

Purity

>98% by SDS-PAGE

Concentration

Bottled at the concentration indicated on the vial.

Buffer

0.01M PBS, pH 7.4, contains no stabilizers or preservatives.

Endotoxin

<1.0 EU/mg as determined by LAL method

Conjugation

Non-conjugated

Formulation

Liquid or Lyophilized powder Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Storage

store at -20°C or -80°C. Avoid repeated freeze.

Type

Antibody

Purposes

For research use only

References 1

Meina Liang, et al. A Novel Pharmacodynamic Biomarker and Mechanistic Modeling Facilitate the Development of Tovetumab, a Monoclonal Antibody Directed Against Platelet-Derived Growth Factor Receptor Alpha, for Cancer Therapy. AAPS J. 2020 Nov 18;23(1):4.

References 2

Naomi Laing, et al. Inhibition of platelet-derived growth factor receptor 伪 by MEDI-575 reduces tumor growth and stromal fibroblast content in a model of non-small cell lung cancer. Mol Pharmacol. 2013 Jun;83(6):1247-56.聽

References 3

References 4

References 5

Product Citations 1

Product Citations 2

https://pubmed.ncbi.nlm.nih.gov/33210183/
https://pubmed.ncbi.nlm.nih.gov/23558446/
https://www.oursmab.com/News/The-tyrosine-protein-kinase-PDGFRA.html

Target Description

Synonyms

platelet-derived growth factor receptor alpha subunit, PDGFR2, CD140a

Biology Area

Cancer Biology;Fibrosis;CD Markers

Function

PDGFRα, is a tyrosine kinase receptor that, when activated by PDGF ligands, promotes fibroblast activation, tissue remodeling, and cell growth. Tovetumab's inhibition of PDGFRα aims to reduce pathological fibrosis, slow disease progression, and potentially inhibit tumor stroma formation in veterinary malignancies. Its species-specific design ensures optimal safety and efficacy in companion animals.

Additional Articles 1

The-tyrosine-protein-kinase-PDGFRA

Additional Articles 2

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