Trinbelimab (Biosimilar Reference Antibody) (RhD)
Trinbelimab (Biosimilar Reference Antibody) (RhD)-RA0635-Oursmab determined by SDS-PAGE. The purity of the protein is greater than 98%.
Trinbelimab (Biosimilar Reference Antibody) (RhD)

Catalog: 

RA0635

Target

RhD/CD240D/RhPI

Isotype

IgG1 - lambda

Applications

ELISA;FC;Functional Assays;IF

Reactivities

Human

Size (＄)：

100 μg-50;1 mg-210;5 mg-500;10 mg-800;25 mg-1750;50 mg-3000;100 mg-4600

Data Sheet

Material Safety Data Sheet

Certificate of Analysis

Product Description

Trinbelimab is a recombinant human IgG1 lambda monoclonal antibody targeting Rh(D) antigen on red blood cells. As an anti-Rh(D) immunoglobulin, it binds to Rh(D)-positive fetal red blood cells that may enter maternal circulation during pregnancy or after delivery, facilitating their clearance by the maternal immune system to prevent sensitization. It is used for the prevention of hemolytic disease of the fetus and newborn (HDFN) in Rh(D)-negative pregnant women at risk of Rh incompatibility.

Synonyms

r Anti-D, r-anti-D

CAS

2415078-44-1

Isotype

IgG1 - lambda

Host

Genetically human

Target

RhD/CD240D/RhPI

Reactivity

Human

Expression System

CHO

Applications

ELISA, FC, Functional Assays, IF; Recommended dilution: FC, IF:1:200

Purity

>98% by SDS-PAGE

Concentration

Bottled at the concentration indicated on the vial.

Buffer

0.01M PBS, pH 7.4, contains no stabilizers or preservatives.

Endotoxin

<1.0 EU/mg as determined by LAL method

Conjugation

Non-conjugated

Formulation

Liquid or Lyophilized powder Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Storage

store at -20°C or -80°C. Avoid repeated freeze.

Type

Antibody

Purposes

For research use only

References 1

Rahul Vishwanath Mayekar, et al. Recombinant anti-D for prevention of maternal-foetal Rh(D) alloimmunization: a randomized multi-centre clinical trial. Obstet Gynecol Sci. 2020 May;63(3):315-322.

References 2

References 3

References 4

References 5

Product Citations 1

Product Citations 2

https://pubmed.ncbi.nlm.nih.gov/32489976/

Target Description

Synonyms

Rhesus blood group D antigen, RhD, CD240D

Biology Area

Hematology;Immunology;CD Markers

Function

Rh(D) antigen, is a immunogenic protein on red blood cells. Trinbelimab’s mechanism involves opsonizing Rh(D)-positive erythrocytes, leading to their phagocytosis and destruction before the maternal immune system can generate anti-Rh(D) antibodies. This prophylactic approach effectively reduces the risk of HDFN in subsequent pregnancies, representing a well-established immunoprophylactic strategy in obstetrics.

Additional Articles 1

Additional Articles 2

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