Ucenprubart (Biosimilar Reference Antibody) (MOX2R)
Ucenprubart (Biosimilar Reference Antibody) (MOX2R)
Ucenprubart (Biosimilar Reference Antibody) (MOX2R)-RA0492-Oursmab determined by SDS-PAGE. The purity of the protein is greater than 98%.
ELISA plate pre-coated Antigen protein, can bind Ucenprubart (Biosimilar Reference Antibody) (MOX2R)-RA0492 in a linear range of 15.63–31.25 ng/mL.
Ucenprubart (Biosimilar Reference Antibody) (MOX2R)

Catalog: 

RA0492

Target

MOX2R/CD200R1

Isotype

IgG4 - kappa

Applications

ELISA;FC;Functional Assays;IF

Reactivities

Human

Size (＄)：

100 μg-50;1 mg-210;5 mg-500;10 mg-800;25 mg-1750;50 mg-3000;100 mg-4600

Data Sheet

Material Safety Data Sheet

Certificate of Analysis

Product Description

Ucenprubart is a humanized IgG4 kappa monoclonal antibody targeting CD200 receptor 1 (CD200R1), an inhibitory immune checkpoint receptor expressed on myeloid cells and lymphocytes. It binds to CD200R1 to block its interaction with the ligand CD200 (often overexpressed on tumor cells), thereby reversing immunosuppressive signals in the tumor microenvironment. It is being developed for cancer immunotherapy, aiming to enhance anti-tumor immunity in solid tumors and hematologic malignancies.

Synonyms

CAS

2414559-57-0

Isotype

IgG4 - kappa

Host

Humanised

Target

MOX2R/CD200R1

Reactivity

Human

Expression System

CHO

Applications

ELISA, FC, Functional Assays, IF; Recommended dilution: FC, IF:1:200

Purity

>98% by SDS-PAGE

Concentration

Bottled at the concentration indicated on the vial.

Buffer

0.01M PBS, pH 7.4, contains no stabilizers or preservatives.

Endotoxin

<1.0 EU/mg as determined by LAL method

Conjugation

Non-conjugated

Formulation

Liquid or Lyophilized powder Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Storage

store at -20°C or -80°C. Avoid repeated freeze.

Type

Antibody

Purposes

For research use only

References 1

Ucenprubart

References 2

References 3

References 4

References 5

Product Citations 1

Product Citations 2

https://www.imgt.org/mAb-DB/mAbcard?AbId=1515
https://www.oursmab.com/News/Immune-checkpoint-protein-CD200.html

Target Description

Synonyms

CD200 receptor 1, MOX2 receptor, MOX2R, OX2R, HCRTR2

Biology Area

Immune Checkpoint;Immunology;CD Markers

Function

CD200R1, transmits inhibitory signals that suppress macrophage and T cell activation, contributing to immune evasion. Ucenprubart’s blockade of the CD200–CD200R1 axis aims to restore immune cell function, promote antigen presentation, and overcome resistance to existing checkpoint therapies. Its IgG4 isotype minimizes Fc-mediated effector functions, focusing on checkpoint modulation rather than cell depletion.

Additional Articles 1

Immune-checkpoint-protein-CD200

Additional Articles 2

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