Umesolerbart (Biosimilar Reference Antibody) (Bet v 1)
Umesolerbart (Biosimilar Reference Antibody) (Bet v 1)
Umesolerbart (Biosimilar Reference Antibody) (Bet v 1)-RA0037-Oursmab determined by SDS-PAGE. The purity of the protein is greater than 98%.
ELISA plate pre-coated Antigen protein, can bind Umesolerbart (Biosimilar Reference Antibody) (Bet v 1)-RA0037 in a linear range of 15.63–125 ng/mL.
Umesolerbart (Biosimilar Reference Antibody) (Bet v 1)

Catalog: 

RA0037

Target

Bet v 1

Isotype

IgG4 - kappa

Applications

Functional Assays

Reactivities

Betula alleghaniensis

Size (＄)：

100 μg-50;1 mg-210;5 mg-500;10 mg-800;25 mg-1750;50 mg-3000;100 mg-4600

Data Sheet

Material Safety Data Sheet

Certificate of Analysis

Product Description

Umesolerbart is a humanized IgG4 kappa monoclonal antibody specifically targeting Bet v 1, the major allergenic protein in birch pollen. It binds to Bet v 1 to neutralize its allergenicity, preventing IgE-mediated cross-linking on mast cells and basophils. It is being developed for the treatment of birch pollen allergy, aiming to reduce allergic symptoms such as rhinitis, conjunctivitis, and asthma exacerbations during pollen season.

Synonyms

REGN5713-5714-5715, REGN-5714, REGN5714

CAS

2456307-11-0

Isotype

IgG4 - kappa

Host

Genetically human

Target

Bet v 1

Reactivity

Betula alleghaniensis

Expression System

CHO

Applications

Functional Assays;

Purity

>98% by SDS-PAGE

Concentration

Bottled at the concentration indicated on the vial.

Buffer

0.01M PBS, pH 7.4, contains no stabilizers or preservatives.

Endotoxin

<1.0 EU/mg as determined by LAL method

Conjugation

Non-conjugated

Formulation

Liquid or Lyophilized powder Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Storage

store at -20°C or -80°C. Avoid repeated freeze.

Type

Antibody

Purposes

For research use only

References 1

Philippe Gevaert, et al. Novel antibody cocktail targeting Bet v 1 rapidly and sustainably treats birch allergy symptoms in a phase 1 study. J Allergy Clin Immunol. 2022 Jan;149(1):189-199.

References 2

References 3

References 4

References 5

Product Citations 1

Product Citations 2

https://pubmed.ncbi.nlm.nih.gov/34126156/

Target Description

Synonyms

birch Major pollen allergen Bet v 1-A, Allergen Bet v I-A, Bet v 1-A

Biology Area

Immunology;Allergy

Function

Bet v 1, is a pathogenesis-related protein (PR-10) that triggers type I hypersensitivity in sensitized individuals. Umesolerbart’s high-affinity binding blocks the interaction between Bet v 1 and allergen-specific IgE, inhibiting mast cell degranulation and the release of histamine and other inflammatory mediators. This approach offers a targeted immunotherapy for birch pollen allergy, potentially providing seasonal symptom control without the need for allergen desensitization.

Additional Articles 1

Additional Articles 2

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