Upinitatug (Biosimilar Reference Antibody) (SLC34A2)
Upinitatug (Biosimilar Reference Antibody) (SLC34A2)-RA0692-Oursmab determined by SDS-PAGE. The purity of the protein is greater than 98%.
Upinitatug (Biosimilar Reference Antibody) (SLC34A2)

Catalog: 

RA0692

Target

SLC34A2

Isotype

IgG1 - kappa

Applications

ELISA;FC;Functional Assays;IF

Reactivities

Human

Size (＄)：

100 μg-50;1 mg-210;5 mg-500;10 mg-800;25 mg-1750;50 mg-3000;100 mg-4600

Data Sheet

Material Safety Data Sheet

Certificate of Analysis

Product Description

Upinitatug is a human IgG1 kappa monoclonal antibody targeting sodium-dependent phosphate transporter 2b (NaPi-2b, also known as NPT2B or NAPI-IIb), a cell surface protein overexpressed in ovarian cancer and other epithelial malignancies. It binds to NaPi-2b to inhibit phosphate transport and tumor growth, and is often developed as an antibody-drug conjugate (ADC) to deliver cytotoxic agents directly to NaPi-2b-positive cancer cells. It is being investigated for the treatment of advanced ovarian cancer and other NaPi-2b-expressing solid tumors.

Synonyms

XMT-1536

CAS

2254119-00-9

Isotype

IgG1 - kappa

Host

Chimeric and/or humanised

Target

SLC34A2

Reactivity

Human

Expression System

CHO

Applications

ELISA, FC, Functional Assays, IF; Recommended dilution: FC, IF:1:200

Purity

>98% by SDS-PAGE

Concentration

Bottled at the concentration indicated on the vial.

Buffer

0.01M PBS, pH 7.4, contains no stabilizers or preservatives.

Endotoxin

<1.0 EU/mg as determined by LAL method

Conjugation

Non-conjugated

Formulation

Liquid or Lyophilized powder Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Storage

store at -20°C or -80°C. Avoid repeated freeze.

Type

Antibody

Purposes

For research use only

References 1

IMGT

References 2

References 3

References 4

References 5

Product Citations 1

Product Citations 2

https://www.imgt.org/mAb-DB/mAbcard?AbId=1036
https://www.oursmab.com/News/Sodium-dependent-phosphate-transporter-SLC34A2.html

Target Description

Synonyms

solute carrier family 34 sodium phosphate member 2, sodium/phosphate cotransporter 2B, NaPi2b, NaPi3b, NAPI-3B

Biology Area

Cancer Biology;Metabolism

Function

NaPi-2b, is a transmembrane protein involved in phosphate homeostasis and is aberrantly expressed in many epithelial cancers. Upinitatug's binding to NaPi-2b enables targeted delivery of potent chemotherapeutic payloads (e.g., microtubule inhibitors or DNA-damaging agents) to tumor cells, inducing apoptosis while sparing normal tissues.

Additional Articles 1

Sodium-dependent-phosphate-transporter-SLC34A2

Additional Articles 2

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