Venanprubart (Biosimilar Reference Antibody) (BTLA)
Venanprubart (Biosimilar Reference Antibody) (BTLA)-RA0041-Oursmab determined by SDS-PAGE. The purity of the protein is greater than 98%.
Venanprubart (Biosimilar Reference Antibody) (BTLA)

Catalog: 

RA0041

Target

BTLA/CD272

Isotype

IgG4 - kappa

Applications

ELISA;FC;Functional Assays;IF

Reactivities

Human

Size (＄)：

100 μg-50;1 mg-210;5 mg-500;10 mg-800;25 mg-1750;50 mg-3000;100 mg-4600

Data Sheet

Material Safety Data Sheet

Certificate of Analysis

Product Description

Enanprubart is an investigational humanized monoclonal antibody of the IgG4-kappa isotype that specifically targets the B- and T-lymphocyte attenuator (BTLA). Designed to block the inhibitory interaction between BTLA and its ligand HVEM, it aims to enhance anti-tumor immune responses and is currently being evaluated in clinical trials for the treatment of various advanced solid tumors.

Synonyms

CAS

2635407-50-8

Isotype

IgG4 - kappa

Host

Humanised

Target

BTLA/CD272

Reactivity

Human

Expression System

CHO

Applications

ELISA, FC, Functional Assays, IF; Recommended dilution: FC, IF:1:200

Purity

>98% by SDS-PAGE

Concentration

Bottled at the concentration indicated on the vial.

Buffer

0.01M PBS, pH 7.4, contains no stabilizers or preservatives.

Endotoxin

<1.0 EU/mg as determined by LAL method

Conjugation

Non-conjugated

Formulation

Liquid or Lyophilized powder Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Storage

store at -20°C or -80°C. Avoid repeated freeze.

Type

Antibody

Purposes

For research use only

References 1

Venanprubart

References 2

References 3

References 4

References 5

Product Citations 1

Product Citations 2

https://www.imgt.org/mAb-DB/mAbcard?AbId=1518
https://www.oursmab.com/News/B-and-T-lymphocyte-attenuator-BTLA.html

Target Description

Synonyms

B and T lymphocyte associated, BTLA1, CD272

Biology Area

Immune Checkpoint;Immunology;CD Markers

Function

BTLA is an immune checkpoint receptor primarily expressed on T and B lymphocytes. By binding to its ligand HVEM, BTLA transmits an inhibitory signal that dampens lymphocyte activation and proliferation, functioning as a natural brake on the immune system. In the tumor microenvironment, this pathway can suppress anti-tumor immunity, making BTLA a strategic target for cancer immunotherapy.

Additional Articles 1

B-and-T-lymphocyte-attenuator-BTLA

Additional Articles 2

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