Vilamakitug (Biosimilar Reference Antibody) (IL1A)
Vilamakitug (Biosimilar Reference Antibody) (IL1A)
Vilamakitug (Biosimilar Reference Antibody) (IL1A)-RA0355-Oursmab determined by SDS-PAGE. The purity of the protein is greater than 98%.
ELISA plate pre-coated Antigen protein, can bind Vilamakitug (Biosimilar Reference Antibody) (IL1A)-RA0355 in a linear range of 15.63–125 ng/mL.
Vilamakitug (Biosimilar Reference Antibody) (IL1A)

Catalog: 

RA0355

Target

IL1A

Isotype

IgG4 - kappa

Applications

ELISA;FC;Functional Assays;IF

Reactivities

Human

Size (＄)：

100 μg-50;1 mg-210;5 mg-500;10 mg-800;25 mg-1750;50 mg-3000;100 mg-4600

Data Sheet

Material Safety Data Sheet

Certificate of Analysis

Product Description

Vilamakitug (XB-2001) is an investigational human monoclonal antibody of the IgG4 κ isotype that specifically targets interleukin-1 alpha (IL-1α). It is designed to neutralize this key pro-inflammatory cytokine, with potential therapeutic applications in inflammatory and autoimmune diseases where IL-1α plays a central role in driving tissue inflammation and damage.

Synonyms

XB-2001, XB2001

CAS

2458202-06-5

Isotype

IgG4 - kappa

Host

Genetically human

Target

IL1A

Reactivity

Human

Expression System

CHO

Applications

ELISA, FC, Functional Assays, IF; Recommended dilution: FC, IF:1:200

Purity

>98% by SDS-PAGE

Concentration

Bottled at the concentration indicated on the vial.

Buffer

0.01M PBS, pH 7.4, contains no stabilizers or preservatives.

Endotoxin

<1.0 EU/mg as determined by LAL method

Conjugation

Non-conjugated

Formulation

Liquid or Lyophilized powder Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Storage

store at -20°C or -80°C. Avoid repeated freeze.

Type

Antibody

Purposes

For research use only

References 1

Vilamakitug

References 2

References 3

References 4

References 5

Product Citations 1

Product Citations 2

https://www.imgt.org/mAb-DB/mAbcard?AbId=1311
https://www.oursmab.com/News/Inflammatory-cytokine-IL1β.html

Target Description

Synonyms

interleukin 1 alpha

Biology Area

Cytokine and Chemokine;Immunology

Function

Interleukin-1 alpha is a potent pro-inflammatory cytokine that functions both as a secreted signaling molecule and as an “alarmin” released from damaged or necrotic cells to initiate and amplify inflammation. By binding to the same receptor (IL-1R1) as IL-1β, IL-1α triggers a cascade of inflammatory responses. Targeting IL-1α specifically with vilamakitug aims to block this early and localized inflammatory signal, particularly in conditions involving tissue injury or epithelial inflammation, such as certain dermatologic or rheumatologic diseases.

Additional Articles 1

Inflammatory-cytokine-IL1β

Additional Articles 2

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