Zigakibart (Biosimilar Reference Antibody) (TNFSF13)
Zigakibart (Biosimilar Reference Antibody) (TNFSF13)
Zigakibart (Biosimilar Reference Antibody) (TNFSF13)-RA0788-Oursmab determined by SDS-PAGE. The purity of the protein is greater than 98%.
ELISA plate pre-coated Antigen protein, can bind Zigakibart (Biosimilar Reference Antibody) (TNFSF13)-RA0788 in a linear range of 15.63–125 ng/mL.
Zigakibart (Biosimilar Reference Antibody) (TNFSF13)

Catalog: 

RA0788

Target

TNFSF13/CD256/APRIL

Isotype

IgG4 - kappa

Applications

ELISA;FC;Functional Assays;IF

Reactivities

Human

Size (＄)：

100 μg-50;1 mg-210;5 mg-500;10 mg-800;25 mg-1750;50 mg-3000;100 mg-4600

Data Sheet

Material Safety Data Sheet

Certificate of Analysis

Product Description

Zigakibart is an investigational humanized monoclonal antibody of the IgG4 isotype that specifically targets and neutralizes A Proliferation-Inducing Ligand (APRIL). It is being developed for the treatment of autoimmune diseases driven by pathogenic B cells and autoantibodies, such as systemic lupus erythematosus (SLE) and IgA nephropathy (IgAN), aiming to disrupt B cell survival and class-switching.

Synonyms

BION-1301, BION1301

CAS

2642175-46-8

Isotype

IgG4 - kappa

Host

Humanised

Target

TNFSF13/CD256/APRIL

Reactivity

Human

Expression System

CHO

Applications

ELISA, FC, Functional Assays, IF; Recommended dilution: FC, IF:1:200

Purity

>98% by SDS-PAGE

Concentration

Bottled at the concentration indicated on the vial.

Buffer

0.01M PBS, pH 7.4, contains no stabilizers or preservatives.

Endotoxin

<1.0 EU/mg as determined by LAL method

Conjugation

Non-conjugated

Formulation

Liquid or Lyophilized powder Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Storage

store at -20°C or -80°C. Avoid repeated freeze.

Type

Antibody

Purposes

For research use only

References 1

International Nonproprietary Names for Pharmaceutical Substances (INN). WHO Drug Information, Vol. 36, No. 2, 2022.

References 2

References 3

References 4

References 5

Product Citations 1

Product Citations 2

https://www.prescrire.org/
https://www.oursmab.com/News/APRIL-is-a-therapeutic-target-for-IgA-nephropathy.html

Target Description

Synonyms

tumor necrosis factor (TNF) superfamily member 13, APRIL, CD256

Biology Area

Cytokine and Chemokine;Immunology;CD Markers

Function

APRIL is a tumor necrosis factor (TNF) family cytokine that signals through the receptors B cell maturation antigen (BCMA) and transmembrane activator and CAML interactor (TACI). It plays a critical role in the survival and maintenance of long-lived plasma cells, as well as in antibody class-switch recombination. In autoimmune diseases, APRIL contributes to the production of pathogenic autoantibodies. By blocking APRIL, zigakibart aims to reduce the survival of autoreactive plasma cells and decrease the levels of pathogenic antibodies.

Additional Articles 1

APRIL-is-a-therapeutic-target-for-IgA-nephropathy

Additional Articles 2

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