Anti-Human CEACAM-1/CD66a Reference Antibody (CM-24)
Anti-Human CEACAM-1/CD66a Reference Antibody (CM-24)-RA0827-Oursmab determined by SDS-PAGE. The purity of the protein is greater than 98%.
Anti-Human CEACAM-1/CD66a Reference Antibody (CM-24)

Catalog: 

RA0827

Target

CEACAM-1/CD66a

Isotype

IgG4 - kappa

Applications

ELISA;FC;Functional Assays;IF

Reactivities

Human

Size ($):

100 μg-50;1 mg-210;5 mg-500;10 mg-800;25 mg-1750;50 mg-3000;100 mg-4600

Data Sheet

Material Safety Data Sheet

Certificate of Analysis

Product Description

CEACAM1 encodes a member of the carcinoembryonic antigen (CEA) gene family, which belongs to the immunoglobulin superfamily. Two subgroups of the CEA family, the CEA cell adhesion molecules and the pregnancy-specific glycoproteins, are located within a 1.2 Mb cluster on the long arm of chromosome 19. Eleven pseudogenes of the CEA cell adhesion molecule subgroup are also found in the cluster. The encoded protein was originally described in bile ducts of liver as biliary glycoprotein. Subsequently, it was found to be a cell-cell adhesion molecule detected on leukocytes, epithelia, and endothelia. The encoded protein mediates cell adhesion via homophilic as well as heterophilic binding to other proteins of the subgroup. Multiple cellular activities have been attributed to the encoded protein, including roles in the differentiation and arrangement of tissue three-dimensional structure, angiogenesis, apoptosis, tumor suppression, metastasis, and the modulation of innate and adaptive immune responses.

Synonyms

CM24, MK 6018, CM 24, MK-6018

CAS

1783801-93-3

Isotype

IgG4 - kappa

Host

Genetically human

Target

CEACAM-1/CD66a

Reactivity

Human

Expression System

CHO

Applications

ELISA,IF; Recommended dilution: WB:1:5000, IF:1:50-1:200, FC:1:100-1:300

Purity

>98% by SDS-PAGE

Concentration

Bottled at the concentration indicated on the vial.

Buffer

0.01M PBS, pH 7.4, contains no stabilizers or preservatives.

Endotoxin

<1.0 EU/mg as determined by LAL method

Conjugation

Non-conjugated

Formulation

Liquid or Lyophilized powder Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Storage

store at -20°C or -80°C. Avoid repeated freeze.

Type

Antibody

Purposes

For research use only

References 1

Götz L, et, al. The role of carcinoembryonic antigen-related cell adhesion molecule 1 in cancer. Tissue Barriers. 2023 Nov 24;14:1295232.

References 2

References 3

References 4

References 5

Product Citations 1

Product Citations 2

Target Description

Synonyms

Biology Area

Immune Checkpoint;Immunology;Cancer Biology;CD Markers

Function

CEACAM-1 (Carcinoembryonic antigen-related cell adhesion molecule 1) is a multifunctional transmembrane glycoprotein. Its primary roles include mediating intercellular adhesion, regulating the immune system by acting as a co-inhibitory receptor, maintaining vascular homeostasis, and controlling cell proliferation and apoptosis.

Additional Articles 1

Additional Articles 2

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Human

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