Anumigilimab (Biosimilar Reference Antibody) (CSF3R)
Anumigilimab (Biosimilar Reference Antibody) (CSF3R)
Anumigilimab (Biosimilar Reference Antibody) (CSF3R)-RA0161-Oursmab determined by SDS-PAGE. The purity of the protein is greater than 98%.
ELISA plate pre-coated Antigen protein, can bind Anumigilimab (Biosimilar Reference Antibody) (CSF3R)-RA0161 in a linear range of 3.91-125 ng/mL.
Anumigilimab (Biosimilar Reference Antibody) (CSF3R)

Catalog: 

RA0161

Target

CSF3R/CD114

Isotype

IgG4 - kappa

Applications

ELISA;FC;Functional Assays;IF

Reactivities

Human

Size (＄)：

100 μg-50;1 mg-210;5 mg-500;10 mg-800;25 mg-1750;50 mg-3000;100 mg-4600

Data Sheet

Material Safety Data Sheet

Certificate of Analysis

Product Description

Anumigilimab (CSL-324) is a fully human monoclonal antibody of the IgG4 isotype that functions as an antagonist targeting the Granulocyte Colony-Stimulating Factor Receptor (G-CSFR). By blocking this receptor, Anumigilimab inhibits the signaling pathway triggered by its ligand, G-CSF. This action is designed to reduce G-CSF-mediated neutrophilia and neutrophil infiltration into inflamed tissues without causing systemic neutropenia (a deficiency in neutrophils). The IgG4 isotype minimizes the risk of target cell depletion via effector functions. Anumigilimab has been investigated as a therapeutic agent for various chronic inflammatory and autoimmune diseases characterized by excessive neutrophil activity and G-CSF dysregulation, such as Hidradenitis Suppurativa.

Synonyms

CSL324, CSL-324, CSL 324, G-CSFR

CAS

2416593-08-1

Isotype

IgG4 - kappa

Host

Genetically human

Target

CSF3R/CD114

Reactivity

Human

Expression System

CHO

Applications

ELISA, FC, Functional Assays, IF; Recommended dilution: FC, IF:1:200

Purity

>98% by SDS-PAGE

Concentration

Bottled at the concentration indicated on the vial.

Buffer

0.01M PBS, pH 7.4, contains no stabilizers or preservatives.

Endotoxin

<1.0 EU/mg as determined by LAL method

Conjugation

Non-conjugated

Formulation

Liquid or Lyophilized powder Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Storage

store at -20°C or -80°C. Avoid repeated freeze.

Type

Antibody

Purposes

For research use only

References 1

Markota Čagalj A, et al. New and Emerging Targeted Therapies for Hidradenitis Suppurativa. Int J Mol Sci. 2022 Mar 29;23(7):3753.

References 2

Rosales Santillan M, et al. Biologic therapies for the treatment of hidradenitis suppurativa. Expert Opin Biol Ther. 2020 Jun;20(6):621-633.

References 3

References 4

References 5

Product Citations 1

Product Citations 2

https://pubmed.ncbi.nlm.nih.gov/35409118/
https://pubmed.ncbi.nlm.nih.gov/32077334/
https://www.oursmab.com/News/Granulocyte-colony-stimulating-factor-receptor-CSF3R.html

Target Description

Synonyms

colony stimulating factor 3 receptor, CD114, colony stimulating factor 3 receptor (granulocyte), GCSFR

Biology Area

Cytokine Receptor;CD Markers;Immunology

Function

Granulocyte Colony-Stimulating Factor Receptor (G-CSFR), also known as Colony Stimulating Factor 3 Receptor (CSF3R) or CD114. In certain chronic inflammatory and autoimmune conditions, elevated levels of G-CSF drive excessive neutrophil production and their enhanced migration into the affected tissues, contributing significantly to the pathology. Anumigilimab blocks G-CSF from binding to G-CSFR, thus inhibiting the downstream signaling (e.g., STAT3 phosphorylation) that drives this pathological neutrophilia and inflammatory cell infiltration.

Additional Articles 1

Granulocyte-colony-stimulating-factor-receptor-CSF3R

Additional Articles 2

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