L-selectin (CD62L), a calcium-dependent (C-type) lectin and cell adhesion molecule belonging to the selectin family. It is constitutively expressed on most circulating leukocytes, including naive T cells, central memory T cells, B cells, monocytes, and neutrophils. L-selectin's primary physiological role is to mediate the initial, low-affinity attachment (tethering and rolling) of these cells on high endothelial venules (HEVs) in lymph nodes and on activated endothelium at sites of peripheral inflammation. It binds to ligands such as GlyCAM-1, CD34, and MadCAM-1, which are presented on endothelial cells. In pathological inflammation, L-selectin-mediated recruitment contributes to the influx of immune cells into tissues, driving damage.