Atezolizumab (Biosimilar Reference Antibody) (PDL1)
Atezolizumab (Biosimilar Reference Antibody) (PDL1)
Atezolizumab (Biosimilar Reference Antibody) (PDL1)-RA0593-Oursmab determined by SDS-PAGE. The purity of the protein is greater than 98%.
ELISA plate pre-coated Antigen protein, can bind Atezolizumab (Biosimilar Reference Antibody) (PDL1)-RA0593 in a linear range of 3.91-125 ng/mL.
Atezolizumab (Biosimilar Reference Antibody) (PDL1)

Catalog: 

RA0593

Target

PDL1/CD274

Isotype

IgG1 - kappa

Applications

ELISA;FC;Functional Assays;IF

Reactivities

Human

Size ($):

100 μg-50;1 mg-210;5 mg-500;10 mg-800;25 mg-1750;50 mg-3000;100 mg-4600

Data Sheet

Material Safety Data Sheet

Certificate of Analysis

Product Description

Atezolizumab is a fully humanized, engineered monoclonal antibody of the IgG1 isotype, designed as an immune checkpoint inhibitor. It specifically targets programmed death-ligand 1 (PD-L1), blocking its interaction with the PD-1 and B7.1 (CD80) receptors on immune cells. This blockade releases inhibitory signals on T cells, thereby reinvigorating the anti-tumor immune response. Developed by Genentech/Roche, it is approved for the treatment of multiple advanced cancers, including non-small cell lung cancer (NSCLC), small cell lung cancer (SCLC), triple-negative breast cancer (TNBC), hepatocellular carcinoma (HCC), and urothelial carcinoma, often in combination with chemotherapy or other agents.

Synonyms

MPDL3280A, RG7446

CAS

1380723-44-3

Isotype

IgG1 - kappa

Host

Humanised

Target

PDL1/CD274

Reactivity

Human

Expression System

CHO

Applications

ELISA, FC, Functional Assays, IF; Recommended dilution: FC, IF:1:200

Purity

>98% by SDS-PAGE

Concentration

Bottled at the concentration indicated on the vial.

Buffer

0.01M PBS, pH 7.4, contains no stabilizers or preservatives.

Endotoxin

<1.0 EU/mg as determined by LAL method

Conjugation

Non-conjugated

Formulation

Liquid or Lyophilized powder Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Storage

store at -20°C or -80°C. Avoid repeated freeze.

Type

Antibody

Purposes

For research use only

References 1

Cha E, et al. PD-L1 inhibition with MPDL3280A for solid tumors. Semin Oncol. 2015 Jun;42(3):484-7.

References 2

Liu Z, et al. Targeting autophagy enhances atezolizumab-induced mitochondria-related apoptosis in osteosarcoma. Cell Death Dis. 2021;12(2):164. Published 2021 Feb 8.

References 3

References 4

References 5

Product Citations 1

Product Citations 2

https://pubmed.ncbi.nlm.nih.gov/25965367/
https://pubmed.ncbi.nlm.nih.gov/33558476/
https://www.oursmab.com/News/Tumor-escape-switch-PD-1-PD-L1.html

Target Description

Synonyms

programmed cell death 1 ligand 1, B7H1, B7-H1, PDL1, PD-L1, PDCD1L1, B7 homolog 1, B7 homologue 1

Biology Area

Immune Checkpoint;CD Markers;Immunology;Cancer Biology

Function

Programmed Death-Ligand 1 (PD-L1; also known as B7-H1 or CD274), a transmembrane protein frequently overexpressed on tumor cells and tumor-infiltrating immune cells in response to inflammatory signals (particularly interferon-gamma). PD-L1 functions as a key suppressive ligand in the tumor microenvironment.

Additional Articles 1

Tumor-escape-switch-PD-1-PD-L1

Additional Articles 2

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