Atibuclimab (Biosimilar Reference Antibody) (CD14)
Atibuclimab (Biosimilar Reference Antibody) (CD14)
Atibuclimab (Biosimilar Reference Antibody) (CD14)-RA0067-Oursmab determined by SDS-PAGE. The purity of the protein is greater than 98%.
ELISA plate pre-coated Antigen protein, can bind Atibuclimab (Biosimilar Reference Antibody) (CD14)-RA0067 in a linear range of 3.91-500 ng/mL.
Atibuclimab (Biosimilar Reference Antibody) (CD14)

Catalog: 

RA0067

Target

CD14

Isotype

IgG4 - kappa

Applications

ELISA;FC;Functional Assays;IF

Reactivities

Human

Size (＄)：

100 μg-50;1 mg-210;5 mg-500;10 mg-800;25 mg-1750;50 mg-3000;100 mg-4600

Data Sheet

Material Safety Data Sheet

Certificate of Analysis

Product Description

Atibuclimab (IC14) is a chimeric monoclonal antibody composed of murine variable regions and a human IgG4 Fc region. It functions as an antagonist targeting the CD14 glycoprotein. By binding to both membrane-bound (mCD14) and soluble (sCD14) forms of its target, Atibuclimab inhibits the signaling pathway initiated by microbial products like Lipopolysaccharide (LPS) (endotoxin). This blockade attenuates the resultant massive release of pro-inflammatory cytokines (e.g., TNFalpha, IL-6) that drive systemic inflammation. The IgG4 isotype is chosen to minimize complement activation and antibody-dependent cellular cytotoxicity. Atibuclimab has been extensively investigated as an anti-inflammatory therapeutic for conditions involving hyperinflammation and high levels of circulating bacterial products, such as sepsis, community-acquired pneumonia, and has also been studied for Amyotrophic Lateral Sclerosis (ALS) and Acute Respiratory Distress Syndrome (ARDS).

Synonyms

IC14

CAS

2417175-94-9

Isotype

IgG4 - kappa

Host

Chimeric

Target

CD14

Reactivity

Human

Expression System

CHO

Applications

ELISA, FC, Functional Assays, IF; Recommended dilution: FC, IF:1:200

Purity

>98% by SDS-PAGE

Concentration

Bottled at the concentration indicated on the vial.

Buffer

0.01M PBS, pH 7.4, contains no stabilizers or preservatives.

Endotoxin

<1.0 EU/mg as determined by LAL method

Conjugation

Non-conjugated

Formulation

Liquid or Lyophilized powder Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Storage

store at -20°C or -80°C. Avoid repeated freeze.

Type

Antibody

Purposes

For research use only

References 1

Henderson RD, Agosti JM, McCombe PA, et al. Phase 1b dose-escalation, safety, and pharmacokinetic study of IC14, a monoclonal antibody against CD14, for the treatment of amyotrophic lateral sclerosis. Medicine (Baltimore). 2021;100(42):e27421.

References 2

Verbon A, et al. IC14, an anti-CD14 antibody, inhibits endotoxin-mediated symptoms and inflammatory responses in humans. J Immunol. 2001;166(5):3599-3605.

References 3

References 4

References 5

Product Citations 1

Product Citations 2

https://pubmed.ncbi.nlm.nih.gov/34678870/
https://pubmed.ncbi.nlm.nih.gov/11207321/
https://www.oursmab.com/News/CD14-The-pattern-recognition-receptor-for-LPS.html

Target Description

Synonyms

CD14

Biology Area

Innate Immunity;CD Markers;Immunology

Function

CD14 is a Pattern Recognition Receptor (PRR) and a glycoprotein found primarily on the surface of myeloid cells, such as monocytes and macrophages, and exists in a soluble form (sCD14) in the plasma.

Additional Articles 1

CD14-The-pattern-recognition-receptor-for-LPS

Additional Articles 2

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