Brentuximab (Biosimilar Reference Antibody) (TNFRSF8)
Brentuximab (Biosimilar Reference Antibody) (TNFRSF8)
Brentuximab (Biosimilar Reference Antibody) (TNFRSF8)-RA0779-Oursmab determined by SDS-PAGE. The purity of the protein is greater than 98%.
ELISA plate pre-coated Antigen protein, can bind Brentuximab (Biosimilar Reference Antibody) (TNFRSF8)-RA0779 in a linear range of 3.91-125 ng/mL.
Brentuximab (Biosimilar Reference Antibody) (TNFRSF8)

Catalog: 

RA0779

Target

TNFRSF8/CD30

Isotype

IgG1 - kappa

Applications

ELISA;FC;Functional Assays;IF

Reactivities

Human

Size (＄)：

100 μg-50;1 mg-210;5 mg-500;10 mg-800;25 mg-1750;50 mg-3000;100 mg-4600

Data Sheet

Material Safety Data Sheet

Certificate of Analysis

Product Description

Brentuximab vedotin (Adcetris®) is a targeted antibody-drug conjugate (ADC) approved for treating specific CD30-positive lymphomas, primarily classical Hodgkin lymphoma and systemic anaplastic large cell lymphoma. It consists of an anti-CD30 monoclonal antibody linked to the potent cytotoxic agent monomethyl auristatin E (MMAE) via a protease-cleavable linker. The drug binds to CD30 on lymphoma cells, is internalized, and releases MMAE inside the cell, where it disrupts microtubules, arrests the cell cycle, and induces apoptosis. This targeted approach delivers chemotherapy directly to cancer cells while minimizing damage to healthy tissues.

Synonyms

cAC10-Val-Cit-MMAE, SGN-35

CAS

2088770-90-3

Isotype

IgG1 - kappa

Host

Chimeric

Target

TNFRSF8/CD30

Reactivity

Human

Expression System

CHO

Applications

ELISA, FC, Functional Assays, IF; Recommended dilution: FC, IF:1:200

Purity

>98% by SDS-PAGE

Concentration

Bottled at the concentration indicated on the vial.

Buffer

0.01M PBS, pH 7.4, contains no stabilizers or preservatives.

Endotoxin

<1.0 EU/mg as determined by LAL method

Conjugation

Non-conjugated

Formulation

Liquid or Lyophilized powder Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Storage

store at -20°C or -80°C. Avoid repeated freeze.

Type

Antibody

Purposes

For research use only

References 1

Bhatt S, et al. CD30 targeting with brentuximab vedotin: a novel therapeutic approach to primary effusion lymphoma. Blood. 2013 Aug 15;122(7):1233-42.

References 2

Chen R W, et al. Inhibition of MDR1 overcomes brentuximab vedotin resistance in Hodgkin lymphoma cell line model and is synergistic with brentuximab vedotin in mouse xenograft model[J]. Blood, 2016, 128(22): 752.

References 3

References 4

References 5

Product Citations 1

Product Citations 2

https://pubmed.ncbi.nlm.nih.gov/23838350/
https://www.sciencedirect.com/science/article/pii/S0006497119307530

Target Description

Synonyms

tumor necrosis factor receptor (TNFR) superfamily member 8, KI-1, CD30

Biology Area

Cancer Biology;CD Markers

Function

The target of brentuximab vedotin is CD30 (TNFRSF8), a transmembrane receptor belonging to the tumor necrosis factor superfamily. Under normal physiological conditions, CD30 expression is highly restricted and transient, occurring primarily on a subset of activated T and B lymphocytes. In pathology, it is consistently and highly overexpressed on the surface of malignant cells in classical Hodgkin lymphoma (notably the Reed-Sternberg cells) and anaplastic large cell lymphoma. This tumor-specific expression profile makes CD30 an ideal biomarker for targeted therapy, as the antibody component of the ADC selectively delivers its cytotoxic payload directly to these cancerous cells, sparing most normal tissues.

Additional Articles 1

Additional Articles 2

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