Cetuximab (Biosimilar Reference Antibody) (EGFR)
Cetuximab (Biosimilar Reference Antibody) (EGFR)
Cetuximab (Biosimilar Reference Antibody) (EGFR)-RA0194-Oursmab determined by SDS-PAGE. The purity of the protein is greater than 98%.
ELISA plate pre-coated Antigen protein, can bind Cetuximab (Biosimilar Reference Antibody) (EGFR)-RA0194 in a linear range of 3.91-125 ng/mL.
Cetuximab (Biosimilar Reference Antibody) (EGFR)

Catalog: 

RA0194

Target

EGFR/ERBB1/HER1

Isotype

IgG1 - kappa

Applications

ELISA;FC;Functional Assays;IF

Reactivities

Human

Size (＄)：

100 μg-50;1 mg-210;5 mg-500;10 mg-800;25 mg-1750;50 mg-3000;100 mg-4600

Data Sheet

Material Safety Data Sheet

Certificate of Analysis

Product Description

Cetuximab is a chimeric (mouse/human) monoclonal antibody used as a targeted therapy for certain types of cancer. Marketed under the brand name Erbitux®, it is approved for the treatment of squamous cell carcinoma of the head and neck (SCCHN) and KRAS wild-type, metastatic colorectal cancer (mCRC). It can be used in combination with radiation therapy for locally advanced SCCHN, with chemotherapy for recurrent or metastatic SCCHN and mCRC, or as a monotherapy in patients who have failed prior treatments. Cetuximab works by inhibiting the signaling pathway that drives tumor cell growth and proliferation.

Synonyms

Fab C225, IMC-225

CAS

205923-56-4

Isotype

IgG1 - kappa

Host

Chimeric

Target

EGFR/ERBB1/HER1

Reactivity

Human

Expression System

CHO

Applications

ELISA, FC, Functional Assays, IF; Recommended dilution: FC, IF:1:200

Purity

>98% by SDS-PAGE

Concentration

Bottled at the concentration indicated on the vial.

Buffer

0.01M PBS, pH 7.4, contains no stabilizers or preservatives.

Endotoxin

<1.0 EU/mg as determined by LAL method

Conjugation

Non-conjugated

Formulation

Liquid or Lyophilized powder Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Storage

store at -20°C or -80°C. Avoid repeated freeze.

Type

Antibody

Purposes

For research use only

References 1

Goldstein NI, et al. Biological efficacy of a chimeric antibody to the epidermal growth factor receptor in a human tumor xenograft model. Clin Cancer Res. 1995 Nov;1(11):1311-8.

References 2

Gustafsson H, et al. EPR Oximetry of Cetuximab-Treated Head-and-Neck Tumours in a Mouse Model. Cell Biochem Biophys. 2017 Jul 29.

References 3

References 4

References 5

Product Citations 1

Product Citations 2

https://pubmed.ncbi.nlm.nih.gov/9815926/
https://pubmed.ncbi.nlm.nih.gov/28756482/
https://www.oursmab.com/News/Epidermal-growth-factor-receptor-EGFR.html

Target Description

Synonyms

epidermal growth factor receptor, receptor tyrosine-protein kinase erbB-1, ERBB1, HER1, HER-1, ERBB

Biology Area

Cancer Biology;Tumor Antigens

Function

Epidermal growth factor receptor (EGFR), a transmembrane tyrosine kinase receptor that is overexpressed in many epithelial tumors, including colorectal and head and neck cancers. Upon binding to its natural ligands (e.g., EGF, TGF-α), EGFR forms homodimers or heterodimers, triggering intracellular tyrosine kinase activation and downstream signaling cascades (such as RAS-RAF-MAPK and PI3K-AKT pathways) that promote cell proliferation, survival, angiogenesis, and metastasis.

Additional Articles 1

Epidermal-growth-factor-receptor-EGFR

Additional Articles 2

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