Coltuximab (Biosimilar Reference Antibody) (CD19)
Coltuximab (Biosimilar Reference Antibody) (CD19)
Coltuximab (Biosimilar Reference Antibody) (CD19)-RA0070-Oursmab determined by SDS-PAGE. The purity of the protein is greater than 98%.
ELISA plate pre-coated Antigen protein, can bind Coltuximab (Biosimilar Reference Antibody) (CD19)-RA0070 in a linear range of 3.91-125 ng/mL.
Coltuximab (Biosimilar Reference Antibody) (CD19)

Catalog: 

RA0070

Target

CD19

Isotype

IgG1 - kappa

Applications

ELISA;FC;Functional Assays;IF

Reactivities

Human

Size (＄)：

100 μg-50;1 mg-210;5 mg-500;10 mg-800;25 mg-1750;50 mg-3000;100 mg-4600

Data Sheet

Material Safety Data Sheet

Certificate of Analysis

Product Description

Coltuximab (also known as SAR3419) is an investigational antibody-drug conjugate (ADC) developed for the treatment of B-cell non-Hodgkin lymphoma (NHL). It is designed to deliver a potent cytotoxic agent specifically to cancer cells expressing the CD19 antigen, a hallmark of B-cell malignancies. Clinical trials have evaluated its efficacy, particularly in patients with relapsed or refractory diffuse large B-cell lymphoma (DLBCL), aiming to provide a targeted therapeutic option for this aggressive disease.

Synonyms

SAR3419

CAS

1269764-99-9

Isotype

IgG1 - kappa

Host

Chimeric

Target

CD19

Reactivity

Human

Expression System

CHO

Applications

ELISA, FC, Functional Assays, IF; Recommended dilution: FC, IF:1:200

Purity

>98% by SDS-PAGE

Concentration

Bottled at the concentration indicated on the vial.

Buffer

0.01M PBS, pH 7.4, contains no stabilizers or preservatives.

Endotoxin

<1.0 EU/mg as determined by LAL method

Conjugation

Non-conjugated

Formulation

Liquid or Lyophilized powder Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Storage

store at -20°C or -80°C. Avoid repeated freeze.

Type

Antibody

Purposes

For research use only

References 1

Design of Coltuximab Ravtansine, a CD19-Targeting Antibody-Drug Conjugate (ADC) for the Treatment of B-Cell Malignancies: Structure-Activity Relationships and Preclinical Evaluation

References 2

ABBV-319: a CD19-targeting glucocorticoid receptor modulator antibody-drug conjugate therapy for B-cell malignancies

References 3

References 4

References 5

Product Citations 1

Product Citations 2

https://pubmed.ncbi.nlm.nih.gov/25856201/
https://pubmed.ncbi.nlm.nih.gov/38701407/
https://www.oursmab.com/News/B-lymphocyte-marker-CD19.html

Target Description

Synonyms

B lymphocyte surface antigen B4, Leu-12

Biology Area

Immunology;CD Markers;Cancer Biology

Function

CD19, a B-lineage-specific cell surface glycoprotein expressed from early B-cell development through to the mature B-cell stage, but lost upon differentiation into plasma cells. CD19 is a near-universal marker for B-cell malignancies, making it an attractive target for therapies like ADCs and CAR-T cells.

Additional Articles 1

B-lymphocyte-marker-CD19

Additional Articles 2

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