Coramitug (Biosimilar Reference Antibody) (Misfolded TTR)
Coramitug (Biosimilar Reference Antibody) (Misfolded TTR)
Coramitug (Biosimilar Reference Antibody) (Misfolded TTR)-RA0489-Oursmab determined by SDS-PAGE. The purity of the protein is greater than 98%.
ELISA plate pre-coated Antigen protein, can bind Coramitug (Biosimilar Reference Antibody) (Misfolded TTR)-RA0489 in a linear range of 3.91-125 ng/mL.
Coramitug (Biosimilar Reference Antibody) (Misfolded TTR)

Catalog: 

RA0489

Target

Misfolded TTR

Isotype

IgG1 - kappa

Applications

ELISA;FC;Functional Assays;IF

Reactivities

Human

Size (＄)：

100 μg-50;1 mg-210;5 mg-500;10 mg-800;25 mg-1750;50 mg-3000;100 mg-4600

Data Sheet

Material Safety Data Sheet

Certificate of Analysis

Product Description

Coramitug (formerly PRX004) is an investigational humanized monoclonal antibody developed by Novo Nordisk (from Prothena) for treating Transthyretin Amyloidosis with Cardiomyopathy (ATTR-CM), a heart condition where misfolded TTR protein builds up as amyloid. It works by clearing these harmful TTR amyloid deposits, showing promise in reducing disease markers like NT-proBNP in Phase 2 trials and advancing to Phase 3 (CLEOPATTRA study) to assess its impact on heart failure.

Synonyms

PRX004

CAS

2626841-92-5

Isotype

IgG1 - kappa

Host

Chimeric

Target

Misfolded TTR

Reactivity

Human

Expression System

CHO

Applications

ELISA, FC, Functional Assays, IF; Recommended dilution: FC, IF:1:200

Purity

>98% by SDS-PAGE

Concentration

Bottled at the concentration indicated on the vial.

Buffer

0.01M PBS, pH 7.4, contains no stabilizers or preservatives.

Endotoxin

<1.0 EU/mg as determined by LAL method

Conjugation

Non-conjugated

Formulation

Liquid or Lyophilized powder Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Storage

store at -20°C or -80°C. Avoid repeated freeze.

Type

Antibody

Purposes

For research use only

References 1

Coramitug

References 2

References 3

References 4

References 5

Product Citations 1

Product Citations 2

https://www.imgt.org/mAb-DB/mAbcard?AbId=1472

Target Description

Synonyms

transthyretin

Biology Area

Neuroscience;Metabolism

Function

Misfolded transthyretin (TTR), specifically the disease-causing amyloid fibrils and potentially their toxic oligomeric precursors deposited in cardiac tissue. In ATTR-CM, either mutant or wild-type TTR proteins misfold, aggregate, and form insoluble amyloid fibrils in the myocardium, leading to restrictive cardiomyopathy and heart failure.

Additional Articles 1

Additional Articles 2

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