Depatuxizumab (Biosimilar Reference Antibody) (EGFR)
Depatuxizumab (Biosimilar Reference Antibody) (EGFR)
Depatuxizumab (Biosimilar Reference Antibody) (EGFR)-RA0196-Oursmab determined by SDS-PAGE. The purity of the protein is greater than 98%.
ELISA plate pre-coated Antigen protein, can bind Depatuxizumab (Biosimilar Reference Antibody) (EGFR)-RA0196 in a linear range of 3.91-125 ng/mL.
Depatuxizumab (Biosimilar Reference Antibody) (EGFR)

Catalog: 

RA0196

Target

EGFR/ERBB1/HER1

Isotype

IgG1 - kappa

Applications

ELISA;FC;Functional Assays;IF

Reactivities

Human

Size (＄)：

100 μg-50;1 mg-210;5 mg-500;10 mg-800;25 mg-1750;50 mg-3000;100 mg-4600

Data Sheet

Material Safety Data Sheet

Certificate of Analysis

Product Description

Depatuxizumab mafodotin (also known as ABT-414) was an investigational antibody-drug conjugate (ADC) developed for the treatment of glioblastoma multiforme (GBM), the most common and aggressive primary brain tumor. It combined a humanized monoclonal antibody with a potent cytotoxic payload, designed to selectively target and kill tumor cells overexpressing a specific receptor. Clinical trials evaluated its efficacy, both as monotherapy and in combination with standard chemoradiotherapy (temozolomide), in patients with newly diagnosed or recurrent EGFR-amplified glioblastoma. Despite showing signs of activity, its development was ultimately discontinued after Phase III trials failed to demonstrate a statistically significant improvement in overall survival compared to standard of care.

Synonyms

ABT-806

CAS

1471999-69-5

Isotype

IgG1 - kappa

Host

Chimeric and Humanised

Target

EGFR/ERBB1/HER1

Reactivity

Human

Expression System

CHO

Applications

ELISA, FC, Functional Assays, IF; Recommended dilution: FC, IF:1:200

Purity

>98% by SDS-PAGE

Concentration

Bottled at the concentration indicated on the vial.

Buffer

0.01M PBS, pH 7.4, contains no stabilizers or preservatives.

Endotoxin

<1.0 EU/mg as determined by LAL method

Conjugation

Non-conjugated

Formulation

Liquid or Lyophilized powder Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Storage

store at -20°C or -80°C. Avoid repeated freeze.

Type

Antibody

Purposes

For research use only

References 1

Reilly EB, et al. Characterization of ABT-806, a Humanized Tumor-Specific Anti-EGFR Monoclonal Antibody. Mol Cancer Ther. 2015 May;14(5):1141-51.

References 2

References 3

References 4

References 5

Product Citations 1

Product Citations 2

https://pubmed.ncbi.nlm.nih.gov/25731184/
https://www.oursmab.com/News/Epidermal-growth-factor-receptor-EGFR.html

Target Description

Synonyms

epidermal growth factor receptor, receptor tyrosine-protein kinase erbB-1, ERBB1, HER1, HER-1, ERBB

Biology Area

Cancer Biology;Tumor Antigens

Function

Epidermal growth factor receptor (EGFR), a transmembrane tyrosine kinase receptor belonging to the ERBB family. In many epithelial cancers, EGFR is overexpressed or exhibits constitutive activation due to mutations (e.g., exon 19 deletions, L858R point mutations), leading to uncontrolled cell proliferation, survival, angiogenesis, and metastasis.

Additional Articles 1

Epidermal-growth-factor-receptor-EGFR

Additional Articles 2

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