Domvanalimab (Biosimilar Reference Antibody) (TIGIT)
Domvanalimab (Biosimilar Reference Antibody) (TIGIT)
Domvanalimab (Biosimilar Reference Antibody) (TIGIT)-RA0731-Oursmab determined by SDS-PAGE. The purity of the protein is greater than 98%.
ELISA plate pre-coated Antigen protein, can bind Domvanalimab biosimilar in a linear range of 3.91-125 ng/mL.
Domvanalimab (Biosimilar Reference Antibody) (TIGIT)

Catalog: 

RA0731

Target

TIGIT/WUCAM/VSTM3

Isotype

IgG1 - kappa

Applications

ELISA;FC;Functional Assays;IF

Reactivities

Human

Size (＄)：

100 μg-50;1 mg-210;5 mg-500;10 mg-800;25 mg-1750;50 mg-3000;100 mg-4600

Data Sheet

Material Safety Data Sheet

Certificate of Analysis

Product Description

Domvanalimab (also known as ABBV-154) is an investigational fully human monoclonal antibody developed as an immune checkpoint inhibitor for the treatment of cancer. It functions by targeting a novel inhibitory pathway distinct from the well-known PD-1/PD-L1 and CTLA-4 axes, aiming to overcome resistance to existing immunotherapies. Clinical trials are evaluating its safety and efficacy, often in combination with anti-PD-1 therapies (such as zimberelimab) and/or chemotherapy, in patients with advanced solid tumors, including non-small cell lung cancer (NSCLC) and gastrointestinal cancers.

Synonyms

AB-154

CAS

2368219-35-4

Isotype

IgG1 - kappa

Host

Humanised

Target

TIGIT/WUCAM/VSTM3

Reactivity

Human

Expression System

CHO

Applications

ELISA, FC, Functional Assays, IF; Recommended dilution: FC, IF:1:200

Purity

>98% by SDS-PAGE

Concentration

Bottled at the concentration indicated on the vial.

Buffer

0.01M PBS, pH 7.4, contains no stabilizers or preservatives.

Endotoxin

<1.0 EU/mg as determined by LAL method

Conjugation

Non-conjugated

Formulation

Liquid or Lyophilized powder Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Storage

store at -20°C or -80°C. Avoid repeated freeze.

Type

Antibody

Purposes

For research use only

References 1

Dolgin E. Antibody engineers seek optimal drug targeting TIGIT checkpoint. Nat Biotechnol. 2020 Sep;38(9):1007-1009.

References 2

Zhang Y, et al. Hijacking antibody-induced CTLA-4 lysosomal degradation for safer and more effective cancer immunotherapy. Cell Res. 2019 Aug;29(8):609-627.

References 3

References 4

References 5

Product Citations 1

Product Citations 2

https://pubmed.ncbi.nlm.nih.gov/32887966/
https://pubmed.ncbi.nlm.nih.gov/31267017/
https://www.oursmab.com/News/The-inhibitory-receptor-TIGIT.html

Target Description

Synonyms

T-cell immunoreceptor with Ig domain and ITIM, V-set Ig member 9, VSIG9, V-set and transmembrane member 3, VSTM3

Biology Area

Immune Checkpoint;Immunology

Function

TIGIT (T cell immunoreceptor with Ig and ITIM domains), an inhibitory receptor expressed on activated T cells, natural killer (NK) cells, and regulatory T cells (Tregs). TIGIT binds with high affinity to its ligands CD155 (PVR) and CD112 (PVRL2, nectin-2), which are often overexpressed on tumor cells and antigen-presenting cells within the tumor microenvironment. The TIGIT-CD155/CD112 interaction transmits an inhibitory signal that suppresses T cell and NK cell activation, proliferation, and effector function, contributing to immune evasion.

Additional Articles 1

The-inhibitory-receptor-TIGIT

Additional Articles 2

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