Enapotamab (Biosimilar Reference Antibody) (AXL)
Enapotamab (Biosimilar Reference Antibody) (AXL)
Enapotamab (Biosimilar Reference Antibody) (AXL)-RA0030-Oursmab determined by SDS-PAGE. The purity of the protein is greater than 98%.
ELISA plate pre-coated Antigen protein, can bind Enapotamab (Biosimilar Reference Antibody) (AXL)-RA0030 in a linear range of 3.91-125 ng/mL.
Enapotamab (Biosimilar Reference Antibody) (AXL)

Catalog: 

RA0030

Target

AXL/UFO

Isotype

IgG1 - kappa

Applications

ELISA;FC;Functional Assays;IF

Reactivities

Human

Size (＄)：

100 μg-50;1 mg-210;5 mg-500;10 mg-800;25 mg-1750;50 mg-3000;100 mg-4600

Data Sheet

Material Safety Data Sheet

Certificate of Analysis

Product Description

Enapotamab (development code HuMax-AXL-ADC) is an investigational antibody-drug conjugate (ADC) developed for the treatment of solid tumors. It is engineered by linking a potent cytotoxic drug (a tubulin inhibitor) to a fully human monoclonal antibody via a cleavable linker. Enapotamab functions as a targeted chemotherapy agent, where the antibody component specifically delivers the cytotoxic payload to cancer cells expressing its target receptor. Upon binding, the ADC is internalized into the target cell, where the linker is cleaved, releasing the drug to disrupt microtubule formation, ultimately leading to tumor cell death.

Synonyms

CAS

1912423-61-0

Isotype

IgG1 - kappa

Host

Genetically human

Target

AXL/UFO

Reactivity

Human

Expression System

CHO

Applications

ELISA, FC, Functional Assays, IF; Recommended dilution: FC, IF:1:200

Purity

>98% by SDS-PAGE

Concentration

Bottled at the concentration indicated on the vial.

Buffer

0.01M PBS, pH 7.4, contains no stabilizers or preservatives.

Endotoxin

<1.0 EU/mg as determined by LAL method

Conjugation

Non-conjugated

Formulation

Liquid or Lyophilized powder Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Storage

store at -20°C or -80°C. Avoid repeated freeze.

Type

Antibody

Purposes

For research use only

References 1

IMGT

References 2

Koopman LA, et al. Enapotamab vedotin, an AXL-specific antibody-drug conjugate, shows preclinical antitumor activity in non-small cell lung cancer. JCI Insight. 2019 Nov 1;4(21):e128199.

References 3

References 4

References 5

Product Citations 1

Product Citations 2

https://www.imgt.org/mAb-DB/mAbcard?AbId=813
https://pubmed.ncbi.nlm.nih.gov/31600169/
https://www.oursmab.com/News/Tyrosine-protein-kinase-receptor-AXL.html

Target Description

Synonyms

AXL receptor tyrosine kinase, ARK, JTK11, Tyro7, UFO

Biology Area

Cancer Biology;Immune Modulation

Function

AXL is a member of the TAM (TYRO3, AXL, MERTK) family of receptors and is overexpressed in a wide variety of solid tumors, including non-small cell lung cancer (NSCLC), triple-negative breast cancer (TNBC), ovarian cancer, and pancreatic cancer. Its overexpression is frequently associated with aggressive disease, poor prognosis, metastasis, and resistance to multiple therapies (including chemotherapy, targeted therapy, and immunotherapy).

Additional Articles 1

Tyrosine-protein-kinase-receptor-AXL

Additional Articles 2

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