Nimacimab (Biosimilar Reference Antibody) (CNR1)
Nimacimab (Biosimilar Reference Antibody) (CNR1)
Nimacimab (Biosimilar Reference Antibody) (CNR1)-RA0147-Oursmab determined by SDS-PAGE. The purity of the protein is greater than 98%.
ELISA plate pre-coated Antigen protein, can bind Nimacimab (Biosimilar Reference Antibody) (CNR1)-RA0147 in a linear range of 3.91–31 ng/mL.
Nimacimab (Biosimilar Reference Antibody) (CNR1)

Catalog: 

RA0147

Target

CNR1/CB1

Isotype

IgG4 - kappa

Applications

ELISA;FC;Functional Assays;IF

Reactivities

Human

Size (＄)：

100 μg-50;1 mg-210;5 mg-500;10 mg-800;25 mg-1750;50 mg-3000;100 mg-4600

Data Sheet

Material Safety Data Sheet

Certificate of Analysis

Product Description

Nimacimab (also known as BMS-986141) is an investigational, human monoclonal antibody that targets the cannabinoid type 1 receptor (CB1R), a G protein-coupled receptor (GPCR) primarily expressed in the central nervous system and peripheral tissues. Unlike small-molecule CB1R antagonists that cross the blood-brain barrier and cause neuropsychiatric side effects, nimacimab is designed to be peripherally restricted—it does not significantly penetrate the central nervous system. By selectively blocking CB1R in peripheral tissues (e.g., liver, adipose tissue, gastrointestinal tract), it aims to modulate metabolic pathways without central adverse effects. It is being developed for the treatment of metabolic disorders, particularly non-alcoholic steatohepatitis (NASH) and obesity-related complications.

Synonyms

RYI-018

CAS

2098636-09-8

Isotype

IgG4 - kappa

Host

Humanised

Target

CNR1/CB1

Reactivity

Human

Expression System

CHO

Applications

ELISA, FC, Functional Assays, IF; Recommended dilution: FC, IF:1:200

Purity

>98% by SDS-PAGE

Concentration

Bottled at the concentration indicated on the vial.

Buffer

0.01M PBS, pH 7.4, contains no stabilizers or preservatives.

Endotoxin

<1.0 EU/mg as determined by LAL method

Conjugation

Non-conjugated

Formulation

Liquid or Lyophilized powder Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Storage

store at -20°C or -80°C. Avoid repeated freeze.

Type

Antibody

Purposes

For research use only

References 1

Optimized IMAC-IMAC protocol for phosphopeptide recovery from complex biological samples

References 2

References 3

References 4

References 5

Product Citations 1

Product Citations 2

https://pubmed.ncbi.nlm.nih.gov/20450229/
https://www.oursmab.com/News/The-cannabinoid-receptor-CNR1.html

Target Description

Synonyms

cannabinoid receptor 1, CB1K5, CB-R, CB1, CANN6, CB1A

Biology Area

Metabolism;Neuroscience

Function

The cannabinoid receptor 1 (CB1R) is a G protein-coupled receptor that is widely expressed in the brain (where it mediates the psychoactive effects of cannabinoids) and in peripheral organs such as the liver, adipose tissue, pancreas, and gastrointestinal tract. In the periphery, CB1R activation promotes lipogenesis, insulin resistance, inflammation, and fibrosis, contributing to metabolic dysfunction in conditions like obesity, type 2 diabetes, and NASH.

Additional Articles 1

The-cannabinoid-receptor-CNR1

Additional Articles 2

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