Polzastobart (Biosimilar Reference Antibody) (LILRB2)
Polzastobart (Biosimilar Reference Antibody) (LILRB2)
Polzastobart (Biosimilar Reference Antibody) (LILRB2)-RA0465-Oursmab determined by SDS-PAGE. The purity of the protein is greater than 98%.
ELISA plate pre-coated Antigen protein, can bind Polzastobart (Biosimilar Reference Antibody) (LILRB2)-RA0465 in a linear range of 15.63–125 ng/mL.
Polzastobart (Biosimilar Reference Antibody) (LILRB2)

Catalog: 

RA0465

Target

LILRB2

Isotype

IgG4 - kappa

Applications

ELISA;FC;Functional Assays;IF

Reactivities

Human

Size (＄)：

100 μg-50;1 mg-210;5 mg-500;10 mg-800;25 mg-1750;50 mg-3000;100 mg-4600

Data Sheet

Material Safety Data Sheet

Certificate of Analysis

Product Description

Polzastobart is a humanized IgG4 kappa monoclonal antibody developed as an immunomodulatory therapeutic agent. Its primary mechanism of action is the specific and high-affinity binding to the Leukocyte Immunoglobulin-Like Receptor B2 (LILRB2), also known as ILT4 or CD85d. This receptor is predominantly expressed on myeloid cells such as monocytes, macrophages, dendritic cells, and neutrophils. By blocking LILRB2, polzastobart aims to disrupt its interaction with classical and non-classical MHC class I molecules (HLA-G being a high-affinity ligand).

Synonyms

JTX-8064, JTX8064

CAS

2640981-19-5

Isotype

IgG4 - kappa

Host

Humanised

Target

LILRB2

Reactivity

Human

Expression System

CHO

Applications

ELISA, FC, Functional Assays, IF; Recommended dilution: FC, IF:1:200

Purity

>98% by SDS-PAGE

Concentration

Bottled at the concentration indicated on the vial.

Buffer

0.01M PBS, pH 7.4, contains no stabilizers or preservatives.

Endotoxin

<1.0 EU/mg as determined by LAL method

Conjugation

Non-conjugated

Formulation

Liquid or Lyophilized powder Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Storage

store at -20°C or -80°C. Avoid repeated freeze.

Type

Antibody

Purposes

For research use only

References 1

Kyriakos P. Papadopoulos, et al. Phase 1, first-in-human trial of JTX-8064, an anti-LILRB2/ILT4 monoclonal antibody, as monotherapy and in combination with anti-PD-1 in adult patients with advanced solid tumors (INNATE).

References 2

References 3

References 4

References 5

Product Citations 1

Product Citations 2

https://ascopubs.org/doi/abs/10.1200/JCO.2021.39.15_suppl.TPS2672
https://www.oursmab.com/News/The-target-of-Leukocyte-Immunoglobulin-Like-Receptor-B2-LILRB2.html

Target Description

Synonyms

leukocyte immunoglobulin like receptor B2, ILT4, LIR-2, MIR10, CD85d

Biology Area

Immune Checkpoint;Immunology;CD Markers

Function

Leukocyte Immunoglobulin-Like Receptor B2 (LILRB2/ILT4/CD85d), an inhibitory receptor belonging to the immunoglobulin superfamily. Its expression is largely restricted to myeloid lineage cells. LILRB2 functions as a key immune checkpoint by binding to MHC class I molecules (like HLA-A, -B, -C, and especially HLA-G) expressed on healthy somatic cells and, in pathology, often overexpressed on cancer cells.

Additional Articles 1

The-target-of-Leukocyte-Immunoglobulin-Like-Receptor-B2-LILRB2

Additional Articles 2

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