Prezalumab (Biosimilar Reference Antibody) (ICOSLG)
Prezalumab (Biosimilar Reference Antibody) (ICOSLG)
Prezalumab (Biosimilar Reference Antibody) (ICOSLG)-RA0304-Oursmab determined by SDS-PAGE. The purity of the protein is greater than 98%.
ELISA plate pre-coated Antigen protein, can bind Prezalumab (Biosimilar Reference Antibody) (ICOSLG)-RA0304 in a linear range of 15.63–125 ng/mL.
Prezalumab (Biosimilar Reference Antibody) (ICOSLG)

Catalog: 

RA0304

Target

ICOSLG

Isotype

IgG2 - kappa

Applications

ELISA;FC;Functional Assays;IF

Reactivities

Human

Size (＄)：

100 μg-50;1 mg-210;5 mg-500;10 mg-800;25 mg-1750;50 mg-3000;100 mg-4600

Data Sheet

Material Safety Data Sheet

Certificate of Analysis

Product Description

Prezalumab (also known as AMG 557 or the proposed international nonproprietary name Praelumab) is a humanized IgG2 monoclonal antibody developed for the treatment of autoimmune and inflammatory diseases. It possesses a unique dual-targeting mechanism, designed to simultaneously bind to and neutralize two key immunomodulatory ligands: Inducible T-cell Co-stimulator Ligand (ICOSL) and B-cell Activating Factor (BAFF, also known as BLyS). By inhibiting both ICOSL and BAFF, prezalumab aims to comprehensively suppress pathogenic immune activation. It blocks the ICOS-ICOSL co-stimulatory pathway crucial for T-cell and antigen-presenting cell interactions, and concurrently inhibits the BAFF-mediated survival and differentiation of autoreactive B cells. This combined action targets multiple drivers of autoimmunity.

Synonyms

AMG 557, AMG-557, MEDI-5872

CAS

1523164-68-2

Isotype

IgG2 - kappa

Host

Genetically human

Target

ICOSLG

Reactivity

Human

Expression System

CHO

Applications

ELISA, FC, Functional Assays, IF; Recommended dilution: FC, IF:1:200

Purity

>98% by SDS-PAGE

Concentration

Bottled at the concentration indicated on the vial.

Buffer

0.01M PBS, pH 7.4, contains no stabilizers or preservatives.

Endotoxin

<1.0 EU/mg as determined by LAL method

Conjugation

Non-conjugated

Formulation

Liquid or Lyophilized powder Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Storage

store at -20°C or -80°C. Avoid repeated freeze.

Type

Antibody

Purposes

For research use only

References 1

Dillon SR, et al. Non-Redundant Roles of T Cell Costimulation Pathways in Inflammatory Arthritis Revealed by Dual Blockade of ICOS and CD28 with Acazicolcept (ALPN-101). Arthritis Rheumatol. 2023 Aug;75(8):1344-1356.

References 2

Cheng LE, et al. Brief Report: A Randomized, Double-Blind, Parallel-Group, Placebo-Controlled, Multiple-Dose Study to Evaluate AMG 557 in Patients With Systemic Lupus Erythematosus and Active Lupus Arthritis. Arthritis Rheumatol. 2018 Jul;70(7):1071-1076.

References 3

References 4

References 5

Product Citations 1

Product Citations 2

https://pubmed.ncbi.nlm.nih.gov/36862144/
https://pubmed.ncbi.nlm.nih.gov/29513931/
https://www.oursmab.com/News/Inducible-T-cells-costimulate-ligand-ICOSLG.html

Target Description

Synonyms

inducible T-cell co-stimulator ligand, B7H2, B7-H2, ICOS-L, B7-related protein 1, B7RP1, B7RP-1, B7 homolog 2, B7 homologue 2, GL50, KIAA0653, CD275

Biology Area

Immunology;Immune Checkpoint;CD Markers

Function

ICOSL is expressed on antigen-presenting cells and some non-hematopoietic cells; its interaction with ICOS on activated T-cells provides a potent co-stimulatory signal that promotes T-cell effector functions, germinal center formation, and humoral immunity.

Additional Articles 1

Inducible-T-cells-costimulate-ligand-ICOSLG

Additional Articles 2

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