Puxitatug (Biosimilar Reference Antibody) (VTCN1)
Puxitatug (Biosimilar Reference Antibody) (VTCN1)-RA0818-Oursmab determined by SDS-PAGE. The purity of the protein is greater than 98%.
Puxitatug (Biosimilar Reference Antibody) (VTCN1)

Catalog: 

RA0818

Target

VTCN1/B7H4

Isotype

IgG1 - kappa

Applications

ELISA;FC;Functional Assays;IF

Reactivities

Human

Size (＄)：

100 μg-50;1 mg-210;5 mg-500;10 mg-800;25 mg-1750;50 mg-3000;100 mg-4600

Data Sheet

Material Safety Data Sheet

Certificate of Analysis

Product Description

Puxitatug Samrotecan is an antibody-drug conjugate (ADC) developed by AstraZeneca. It consists of an antibody targeting the B7-H4 protein on cancer cells, linked to the cytotoxic payload Samrotecan, a topoisomerase I inhibitor. Upon binding to B7-H4, the ADC is internalized, releasing the payload to cause DNA damage and inhibit tumor cell replication. It is under evaluation for advanced solid tumors such as breast and endometrial cancer.

Synonyms

CAS

2760250-47-1

Isotype

IgG1 - kappa

Host

Genetically human

Target

VTCN1/B7H4

Reactivity

Human

Expression System

CHO

Applications

ELISA, FC, Functional Assays, IF; Recommended dilution: FC, IF:1:200

Purity

>98% by SDS-PAGE

Concentration

Bottled at the concentration indicated on the vial.

Buffer

0.01M PBS, pH 7.4, contains no stabilizers or preservatives.

Endotoxin

<1.0 EU/mg as determined by LAL method

Conjugation

Non-conjugated

Formulation

Liquid or Lyophilized powder Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Storage

store at -20°C or -80°C. Avoid repeated freeze.

Type

Antibody

Purposes

For research use only

References 1

Marchesi S, et al. Immune-checkpoint targeting drug conjugates: a novel class of promising therapeutic agents for cancer treatment. NPJ Precis Oncol. 2025 Jul 2;9(1):219.

References 2

Kundel Y, et al. Adjuvant chemotherapy and whole abdominal irradiation for gastric carcinoma. Tumori. 2008 Jul-Aug;94(4):469-73.

References 3

References 4

References 5

Product Citations 1

Product Citations 2

https://pubmed.ncbi.nlm.nih.gov/40603576/
https://pubmed.ncbi.nlm.nih.gov/18822680/
https://www.oursmab.com/News/The-immunosuppressive-molecule-B7H4.html

Target Description

Synonyms

V-set domain containing T cell activation inhibitor 1, B7 family member H4, B7H4, B7-H4

Biology Area

Immune Checkpoint;Immunology;Cancer Biology

Function

B7-H4, is an immune-regulatory protein overexpressed on many solid tumors but with limited expression in normal tissues. This selective expression allows the ADC to deliver its cytotoxic agent precisely to the tumor microenvironment, aiming to maximize anti-tumor efficacy while minimizing systemic toxicity.

Additional Articles 1

The-immunosuppressive-molecule-B7H4

Additional Articles 2

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