Quisovalimab (Biosimilar Reference Antibody) (TNFSF14)
Quisovalimab (Biosimilar Reference Antibody) (TNFSF14)-RA0791-Oursmab determined by SDS-PAGE. The purity of the protein is greater than 98%.
Quisovalimab (Biosimilar Reference Antibody) (TNFSF14)

Catalog: 

RA0791

Target

TNFSF14/CD258

Isotype

IgG4 - kappa

Applications

ELISA;FC;Functional Assays;IF

Reactivities

Human

Size (＄)：

100 μg-50;1 mg-210;5 mg-500;10 mg-800;25 mg-1750;50 mg-3000;100 mg-4600

Data Sheet

Material Safety Data Sheet

Certificate of Analysis

Product Description

Quisovalimab is a humanized IgG4 kappa monoclonal antibody that specifically targets LIGHT (TNFSF14), a TNF superfamily cytokine. By binding to and neutralizing LIGHT, it blocks its interaction with the receptors HVEM and LTβR. This mechanism aims to inhibit LIGHT-mediated pro-inflammatory and co-stimulatory signaling pathways, thereby modulating immune responses. It is being investigated for the treatment of autoimmune diseases and inflammatory conditions, such as ulcerative colitis and rheumatoid arthritis.

Synonyms

CERC-002, MDGN-002, SAR-252067, F-19, AEVI-002

CAS

2427667-03-4

Isotype

IgG4 - kappa

Host

Genetically human

Target

TNFSF14/CD258

Reactivity

Human

Expression System

CHO

Applications

ELISA, FC, Functional Assays, IF; Recommended dilution: FC, IF:1:200

Purity

>98% by SDS-PAGE

Concentration

Bottled at the concentration indicated on the vial.

Buffer

0.01M PBS, pH 7.4, contains no stabilizers or preservatives.

Endotoxin

<1.0 EU/mg as determined by LAL method

Conjugation

Non-conjugated

Formulation

Liquid or Lyophilized powder Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Storage

store at -20°C or -80°C. Avoid repeated freeze.

Type

Antibody

Purposes

For research use only

References 1

David S Perlin, et al. Levels of the TNF-Related Cytokine LIGHT Increase in Hospitalized COVID-19 Patients with Cytokine Release Syndrome and ARDS. mSphere. 2020 Aug 12;5(4):e00699-20.

References 2

References 3

References 4

References 5

Product Citations 1

Product Citations 2

https://pubmed.ncbi.nlm.nih.gov/32817460/
https://www.oursmab.com/News/The-target-of-Tumor-necrosis-factor-ligand-superfamily-member14-TNFSF14.html

Target Description

Synonyms

tumor necrosis factor (TNF) superfamily member 14, LIGHT, HVEM-L, CD258

Biology Area

Cytokine and Chemokine;Immunology;CD Markers

Function

LIGHT (TNFSF14), is a key cytokine involved in T cell activation, lymphoid tissue development, and inflammatory pathogenesis. Its signaling through HVEM and LTβR promotes inflammation, tissue damage, and immune cell activation. By neutralizing soluble LIGHT, quisovalimab seeks to reduce the activation of pathogenic T cells and the production of inflammatory cytokines, potentially restoring immune homeostasis in chronic inflammatory diseases.

Additional Articles 1

The-target-of-Tumor-necrosis-factor-ligand-superfamily-member14-TNFSF14

Additional Articles 2

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