Raludotatug (Biosimilar Reference Antibody) (CDH6)
Raludotatug (Biosimilar Reference Antibody) (CDH6)
Raludotatug (Biosimilar Reference Antibody) (CDH6)-RA0135-Oursmab determined by SDS-PAGE. The purity of the protein is greater than 98%.
ELISA plate pre-coated Antigen protein, can bind Raludotatug (Biosimilar Reference Antibody) (CDH6)-RA0135 in a linear range of 15.63–125 ng/mL.
Raludotatug (Biosimilar Reference Antibody) (CDH6)

Catalog: 

RA0135

Target

CDH6

Isotype

IgG1 - kappa

Applications

ELISA;FC;Functional Assays;IF

Reactivities

Human

Size (＄)：

100 μg-50;1 mg-210;5 mg-500;10 mg-800;25 mg-1750;50 mg-3000;100 mg-4600

Data Sheet

Material Safety Data Sheet

Certificate of Analysis

Product Description

Raludotatug is a humanized IgG1 kappa monoclonal antibody designed to target cadherin-6 (CDH6), a cell adhesion protein overexpressed in certain cancers, particularly ovarian cancer and renal cell carcinoma. By binding to CDH6 on the surface of tumor cells, it aims to inhibit tumor progression and metastasis. Its development is focused on evaluating its potential as a monotherapy or in combination with other agents for the treatment of advanced solid tumors.

Synonyms

DS-6000A, DS6000A

CAS

2610074-56-9

Isotype

IgG1 - kappa

Host

Humanised

Target

CDH6

Reactivity

Human

Expression System

CHO

Applications

ELISA, FC, Functional Assays, IF; Recommended dilution: FC, IF:1:200

Purity

>98% by SDS-PAGE

Concentration

Bottled at the concentration indicated on the vial.

Buffer

0.01M PBS, pH 7.4, contains no stabilizers or preservatives.

Endotoxin

<1.0 EU/mg as determined by LAL method

Conjugation

Non-conjugated

Formulation

Liquid or Lyophilized powder Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Storage

store at -20°C or -80°C. Avoid repeated freeze.

Type

Antibody

Purposes

For research use only

References 1

Suzuki H, et al. Raludotatug Deruxtecan, a CDH6-Targeting Antibody-Drug Conjugate with a DNA Topoisomerase I Inhibitor DXd, Is Efficacious in Human Ovarian and Kidney Cancer Models. Mol Cancer Ther. 2024 Mar 4;23(3):257-271.

References 2

References 3

References 4

References 5

Product Citations 1

Product Citations 2

https://pubmed.ncbi.nlm.nih.gov/38205802/
https://www.oursmab.com/News/The-cadherin-CDH6.html

Target Description

Synonyms

cadherin 6, K-cadherin (foetal kidney), cadherin 6 type 2

Biology Area

Tumor Antigens;Cancer Biology

Function

cadherin-6 (CDH6), is a calcium-dependent cell adhesion molecule involved in tissue morphogenesis and cell signaling. In cancer, its aberrant overexpression is associated with increased tumor invasiveness, metastasis, and poor prognosis. Raludotatug's binding to CDH6 may interfere with these pro-tumorigenic functions, potentially suppressing tumor cell migration and invasion, and also enabling antibody-dependent cellular cytotoxicity (ADCC) against CDH6-positive cancer cells.

Additional Articles 1

The-cadherin-CDH6

Additional Articles 2

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