Rolinsatamab (Biosimilar Reference Antibody) (PRLR)
Rolinsatamab (Biosimilar Reference Antibody) (PRLR)-RA0616-Oursmab determined by SDS-PAGE. The purity of the protein is greater than 98%.
Rolinsatamab (Biosimilar Reference Antibody) (PRLR)

Catalog: 

RA0616

Target

PRLR

Isotype

IgG1 - kappa

Applications

ELISA;FC;Functional Assays;IF

Reactivities

Human

Size (＄)：

100 μg-50;1 mg-210;5 mg-500;10 mg-800;25 mg-1750;50 mg-3000;100 mg-4600

Data Sheet

Material Safety Data Sheet

Certificate of Analysis

Product Description

Rolinsatamab is a chimeric IgG1 kappa monoclonal antibody targeting the prolactin receptor (PRLR). It blocks PRLR signaling, which is involved in cell proliferation and survival pathways. It is being developed for the treatment of PRLR-positive cancers, such as certain breast and prostate cancers.

Synonyms

h16f, PR-1594804

CAS

2095467-30-2

Isotype

IgG1 - kappa

Host

Chimeric

Target

PRLR

Reactivity

Human

Expression System

CHO

Applications

ELISA, FC, Functional Assays, IF; Recommended dilution: FC, IF:1:200

Purity

>98% by SDS-PAGE

Concentration

Bottled at the concentration indicated on the vial.

Buffer

0.01M PBS, pH 7.4, contains no stabilizers or preservatives.

Endotoxin

<1.0 EU/mg as determined by LAL method

Conjugation

Non-conjugated

Formulation

Liquid or Lyophilized powder Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Storage

store at -20°C or -80°C. Avoid repeated freeze.

Type

Antibody

Purposes

For research use only

References 1

Anderson MG, et al. ABBV-176, a PRLR antibody drug conjugate with a potent DNA-damaging PBD cytotoxin and enhanced activity with PARP inhibition. BMC Cancer. 2021 Jun 9;21(1):681.

References 2

References 3

References 4

References 5

Product Citations 1

Product Citations 2

https://pubmed.ncbi.nlm.nih.gov/34107902/
https://www.oursmab.com/News/Prolactin-receptor-PRLR.html

Target Description

Synonyms

prolactin receptor

Biology Area

Cancer Biology;Cytokine Receptor

Function

PRLR, is a cytokine receptor activated by prolactin, promoting growth and survival signals in hormone-responsive tissues and tumors. By inhibiting PRLR, rolinsatamab aims to suppress tumor growth and induce apoptosis in cancer cells that depend on this pathway.

Additional Articles 1

Prolactin-receptor-PRLR

Additional Articles 2

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