Sotevtamab (Biosimilar Reference Antibody) (CLU)
Sotevtamab (Biosimilar Reference Antibody) (CLU)-RA0146-Oursmab determined by SDS-PAGE. The purity of the protein is greater than 98%.
Sotevtamab (Biosimilar Reference Antibody) (CLU)

Catalog: 

RA0146

Target

CLU

Isotype

IgG2 - kappa

Applications

ELISA;FC;Functional Assays;IF

Reactivities

Human

Size (＄)：

100 μg-50;1 mg-210;5 mg-500;10 mg-800;25 mg-1750;50 mg-3000;100 mg-4600

Data Sheet

Material Safety Data Sheet

Certificate of Analysis

Product Description

Sotevtamab (AB-16B5) is a humanized IgG2 monoclonal antibody targeting clusterin, a chaperone protein involved in cell survival, epithelial-mesenchymal transition (EMT), and treatment resistance in cancer. It binds to clusterin to inhibit its anti-apoptotic and pro-metastatic functions, thereby suppressing tumor progression and metastasis. It is being developed for the treatment of advanced solid tumors, such as prostate and lung cancers.

Synonyms

AB-16B5, 16B5

CAS

2411526-47-9

Isotype

IgG2 - kappa

Host

Humanised

Target

CLU

Reactivity

Human

Expression System

CHO

Applications

ELISA, FC, Functional Assays, IF; Recommended dilution: FC, IF:1:200

Purity

>98% by SDS-PAGE

Concentration

Bottled at the concentration indicated on the vial.

Buffer

0.01M PBS, pH 7.4, contains no stabilizers or preservatives.

Endotoxin

<1.0 EU/mg as determined by LAL method

Conjugation

Non-conjugated

Formulation

Liquid or Lyophilized powder Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Storage

store at -20°C or -80°C. Avoid repeated freeze.

Type

Antibody

Purposes

For research use only

References 1

Gilles Tremblay, et al. Abstract 1467: AB-16B5, a therapeutic monoclonal antibody against human clusterin that blocks the epithelial-to-mesenchymal transition. Cancer Res 15 April 2010; 70 (8_Supplement): 1467.

References 2

Cristiano Ferrario, et al. Phase 1 first-in-human study of anti-clusterin antibody AB-16B5 in patients with advanced solid malignancies. Cancer Res 1 July 2017; 77 (13_Supplement): CT098.

References 3

References 4

References 5

Product Citations 1

Product Citations 2

https://aacrjournals.org/cancerres/article/70/8_Supplement/1467/561878
https://aacrjournals.org/cancerres/article/77/13_Supplement/CT098/622254/Abstract-CT098-Phase-1-first-in-human-study-of
https://www.oursmab.com/News/Tumor-microenvironment-homeostasis-regulator-CLU.html

Target Description

Synonyms

clusterin, SGP-2, SP-40, TRPM-2, KUB1, CLU1, CLU2

Biology Area

Cancer Biology;Neuroscience

Function

clusterin (CLU), is upregulated in response to cellular stress (e.g., chemotherapy, radiation) and promotes cancer cell survival, EMT, and immune evasion. Sotevtamab's blockade of clusterin disrupts these pathways, potentially reversing therapy resistance, inhibiting metastatic spread, and enhancing tumor cell death in clusterin-overexpressing malignancies.

Additional Articles 1

Tumor-microenvironment-homeostasis-regulator-CLU

Additional Articles 2

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