Tabituximab (Biosimilar Reference Antibody) (FZD10)
Tabituximab (Biosimilar Reference Antibody) (FZD10)
Tabituximab (Biosimilar Reference Antibody) (FZD10)-RA0264-Oursmab determined by SDS-PAGE. The purity of the protein is greater than 98%.
ELISA plate pre-coated Antigen protein, can bind Tabituximab (Biosimilar Reference Antibody) (FZD10)-RA0264 in a linear range of 15.63-125 ng/mL.
Tabituximab (Biosimilar Reference Antibody) (FZD10)

Catalog: 

RA0264

Target

FZD10/CD350

Isotype

IgG1 - kappa

Applications

ELISA;FC;Functional Assays;IF

Reactivities

Human

Size ($):

100 μg-50;1 mg-210;5 mg-500;10 mg-800;25 mg-1750;50 mg-3000;100 mg-4600

Data Sheet

Material Safety Data Sheet

Certificate of Analysis

Product Description

Tabituximab is a humanized IgG1 kappa monoclonal antibody targeting frizzled class receptor 10 (FZD10), a Wnt pathway receptor overexpressed in certain sarcomas and solid tumors. It binds to FZD10 to inhibit Wnt signaling, which drives tumor growth and metastasis, and may also deliver cytotoxic payloads as an antibody-drug conjugate (ADC). It is being developed for the treatment of FZD10-positive cancers, such as synovial sarcoma and colorectal carcinoma.

Synonyms

OTSA101, ONC-005

CAS

1644134-10-0

Isotype

IgG1 - kappa

Host

Chimeric

Target

FZD10/CD350

Reactivity

Human

Expression System

CHO

Applications

ELISA, FC, Functional Assays, IF; Recommended dilution: FC, IF:1:200

Purity

>98% by SDS-PAGE

Concentration

Bottled at the concentration indicated on the vial.

Buffer

0.01M PBS, pH 7.4, contains no stabilizers or preservatives.

Endotoxin

<1.0 EU/mg as determined by LAL method

Conjugation

Non-conjugated

Formulation

Liquid or Lyophilized powder Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Storage

store at -20°C or -80°C. Avoid repeated freeze.

Type

Antibody

Purposes

For research use only

References 1

Blagodatski A, et al. Targeting the Wnt pathways for therapies. Mol Cell Ther. 2014 Sep 11;2:28.

References 2

References 3

References 4

References 5

Product Citations 1

Product Citations 2

https://pubmed.ncbi.nlm.nih.gov/26056595/
https://www.oursmab.com/News/The-Wnt-pathway-activates-the-receptor-family-FZD.html

Target Description

Synonyms

frizzled class receptor 10, frizzled (Drosophila) homolog 10, frizzled 10, seven transmembrane spanning receptor, frizzled family receptor 10, frizzled homolog 10 (Drosophila), CD350

Biology Area

Cancer Biology;Developmental Signaling;CD Markers

Function

FZD10, is a G protein-coupled receptor involved in embryonic development and tissue homeostasis. In cancer, its aberrant activation promotes cell proliferation and invasion. Tabituximab’s binding to FZD10 can block ligand-induced signaling and, as an ADC, deliver toxins (e.g., monomethyl auristatin E) directly to tumor cells, inducing apoptosis while sparing normal tissues with low FZD10 expression.

Additional Articles 1

The-Wnt-pathway-activates-the-receptor-family-FZD

Additional Articles 2

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