Telisotuzumab (Biosimilar Reference Antibody) (MET)
Telisotuzumab (Biosimilar Reference Antibody) (MET)
Telisotuzumab (Biosimilar Reference Antibody) (MET)-RA0485-Oursmab determined by SDS-PAGE. The purity of the protein is greater than 98%.
ELISA plate pre-coated Antigen protein, can bind Telisotuzumab (Biosimilar Reference Antibody) (MET)-RA0485 in a linear range of 15.63–125 ng/mL.
Telisotuzumab (Biosimilar Reference Antibody) (MET)

Catalog: 

RA0485

Target

MET/HGFR

Isotype

IgG1 - kappa

Applications

ELISA;FC;Functional Assays;IF

Reactivities

Human

Size (＄)：

100 μg-50;1 mg-210;5 mg-500;10 mg-800;25 mg-1750;50 mg-3000;100 mg-4600

Data Sheet

Material Safety Data Sheet

Certificate of Analysis

Product Description

Telisotuzumab is a humanized monoclonal antibody targeting c-Met (hepatocyte growth factor receptor), a receptor tyrosine kinase involved in tumor growth and metastasis. It is developed as an antibody-drug conjugate (ADC), linked to a cytotoxic payload (e.g., a microtubule inhibitor), to deliver targeted chemotherapy to c-Met–overexpressing cancer cells. It is being evaluated for the treatment of non-small cell lung cancer (NSCLC) and other solid tumors with c-Met dysregulation.

Synonyms

ABT-700, hz224G11

CAS

1781223-80-0

Isotype

IgG1 - kappa

Host

Humanised

Target

MET/HGFR

Reactivity

Human

Expression System

CHO

Applications

ELISA, FC, Functional Assays, IF; Recommended dilution: FC, IF:1:200

Purity

>98% by SDS-PAGE

Concentration

Bottled at the concentration indicated on the vial.

Buffer

0.01M PBS, pH 7.4, contains no stabilizers or preservatives.

Endotoxin

<1.0 EU/mg as determined by LAL method

Conjugation

Non-conjugated

Formulation

Liquid or Lyophilized powder Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Storage

store at -20°C or -80°C. Avoid repeated freeze.

Type

Antibody

Purposes

For research use only

References 1

Jieyi Wang, et al. Anti-c-Met monoclonal antibody ABT-700 breaks oncogene addiction in tumors with MET amplification. BMC Cancer. 2016 Feb 16;16:105.

References 2

References 3

References 4

References 5

Product Citations 1

Product Citations 2

https://pubmed.ncbi.nlm.nih.gov/26879245/
https://www.oursmab.com/News/Hepatocyte-growth-factor-HGF.html

Target Description

Synonyms

met proto-oncogene, hepatocyte growth factor (HGF) receptor, HGFR, scatter factor (SF) receptor, HGF/SF receptor, receptor tyrosine-protein kinase c-met, papillary renal cell carcinoma 2, RCCP2

Biology Area

Cancer Biology;Tumor Antigens

Function

c-Met, is often overexpressed or mutated in cancers, driving invasive behavior and therapy resistance. Telisotuzumab binds to c-Met on tumor cells, enabling internalization and release of the conjugated cytotoxic agent, which disrupts essential cellular processes and induces apoptosis. This ADC approach aims to improve specificity and efficacy in c-Met–high malignancies while limiting systemic toxicity.

Additional Articles 1

Hepatocyte-growth-factor-HGF

Additional Articles 2

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