Temtokibart (Biosimilar Reference Antibody) (IL22RA1)
Temtokibart (Biosimilar Reference Antibody) (IL22RA1)
Temtokibart (Biosimilar Reference Antibody) (IL22RA1)-RA0364-Oursmab determined by SDS-PAGE. The purity of the protein is greater than 98%.
ELISA plate pre-coated Antigen protein, can bind Temtokibart (Biosimilar Reference Antibody) (IL22RA1)-RA0364 in a linear range of 15.63–125 ng/mL.
Temtokibart (Biosimilar Reference Antibody) (IL22RA1)

Catalog: 

RA0364

Target

IL22RA1

Isotype

IgG1 - lambda

Applications

ELISA;FC;Functional Assays;IF

Reactivities

Human

Size (＄)：

100 μg-50;1 mg-210;5 mg-500;10 mg-800;25 mg-1750;50 mg-3000;100 mg-4600

Data Sheet

Material Safety Data Sheet

Certificate of Analysis

Product Description

Temtokibart is a humanized IgG1 lambda 2 monoclonal antibody targeting interleukin-22 receptor alpha 1 (IL-22RA1), a subunit of the IL-22 receptor complex. It binds to IL-22RA1 to block IL-22 signaling, a pathway involved in epithelial cell repair, inflammation, and tissue fibrosis. It is being developed for the treatment of fibrotic and inflammatory diseases, such as idiopathic pulmonary fibrosis (IPF) and atopic dermatitis.

Synonyms

CAS

2639874-57-8

Isotype

IgG1 - lambda

Host

Humanised

Target

IL22RA1

Reactivity

Human

Expression System

CHO

Applications

ELISA, FC, Functional Assays, IF; Recommended dilution: FC, IF:1:200

Purity

>98% by SDS-PAGE

Concentration

Bottled at the concentration indicated on the vial.

Buffer

0.01M PBS, pH 7.4, contains no stabilizers or preservatives.

Endotoxin

<1.0 EU/mg as determined by LAL method

Conjugation

Non-conjugated

Formulation

Liquid or Lyophilized powder Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Storage

store at -20°C or -80°C. Avoid repeated freeze.

Type

Antibody

Purposes

For research use only

References 1

LEO Pharma presents two late-breaking abstracts for temtokibart reporting positive Phase 2b efficacy, safety and biomarker results in moderate-to-severe atopic dermatitis at the 2025 EADV Annual Meeting in Paris.

References 2

References 3

References 4

References 5

Product Citations 1

Product Citations 2

Target Description

Synonyms

interleukin 22 receptor subunit alpha 1, IL22R

Biology Area

Cytokine Receptor;Immunology

Function

IL-22RA1, is expressed on epithelial and stromal cells, and its activation by IL-22 promotes cell survival, proliferation, and production of pro-inflammatory mediators. Temtokibart's inhibition of IL-22 signaling aims to reduce pathological tissue remodeling, inflammation, and fibrosis, offering a targeted approach for diseases driven by dysregulated IL-22/IL-22RA1 axis activity.

Additional Articles 1

Additional Articles 2

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