Tomaralimab (Biosimilar Reference Antibody) (TLR2)
Tomaralimab (Biosimilar Reference Antibody) (TLR2)
Tomaralimab (Biosimilar Reference Antibody) (TLR2)-RA0740-Oursmab determined by SDS-PAGE. The purity of the protein is greater than 98%.
ELISA plate pre-coated Antigen protein, can bind Tomaralimab (Biosimilar Reference Antibody) (TLR2)-RA0740 in a linear range of 3.91–125 ng/mL.
Tomaralimab (Biosimilar Reference Antibody) (TLR2)

Catalog: 

RA0740

Target

TLR2/CD282

Isotype

IgG4 - kappa

Applications

ELISA;FC;Functional Assays;IF

Reactivities

Human

Size (＄)：

100 μg-50;1 mg-210;5 mg-500;10 mg-800;25 mg-1750;50 mg-3000;100 mg-4600

Data Sheet

Material Safety Data Sheet

Certificate of Analysis

Product Description

Tomaralimab (OPN-305) is a humanized IgG4 monoclonal antibody targeting Toll-like receptor 2 (TLR2), a pattern recognition receptor involved in innate immune activation. It binds to TLR2 to block its interaction with pathogen- and damage-associated molecular patterns (PAMPs/DAMPs), thereby inhibiting downstream pro-inflammatory signaling. It is being developed for the treatment of inflammatory and autoimmune diseases, such as rheumatoid arthritis, atherosclerosis, and organ transplant ischemia-reperfusion injury.

Synonyms

OPN-305

CAS

1449294-76-1

Isotype

IgG4 - kappa

Host

Chimeric

Target

TLR2/CD282

Reactivity

Human

Expression System

CHO

Applications

ELISA, FC, Functional Assays, IF; Recommended dilution: FC, IF:1:200

Purity

>98% by SDS-PAGE

Concentration

Bottled at the concentration indicated on the vial.

Buffer

0.01M PBS, pH 7.4, contains no stabilizers or preservatives.

Endotoxin

<1.0 EU/mg as determined by LAL method

Conjugation

Non-conjugated

Formulation

Liquid or Lyophilized powder Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Storage

store at -20°C or -80°C. Avoid repeated freeze.

Type

Antibody

Purposes

For research use only

References 1

Kim Y, et al. TLR2 immunotherapy suppresses neuroinflammation, tau spread, and memory loss in rTg4510 mice. Brain Behav Immun. 2024 Oct;121:291-302.

References 2

Yeo H, et al. Therapeutic potential of a systemically applied humanized monoclonal antibody targeting Toll-like receptor 2 in atopic-dermatitis-like skin lesions in a mouse model. Biomed Rep. 2024 Dec 30;22(3):41.

References 3

References 4

References 5

Product Citations 1

Product Citations 2

https://pubmed.ncbi.nlm.nih.gov/39098437/
https://pubmed.ncbi.nlm.nih.gov/39781040/
https://www.oursmab.com/News/Pathogen-sensor-TLR2.html

Target Description

Synonyms

toll like receptor 2, toll-like receptor 2, TIL4, CD282

Biology Area

Innate Immunity;Immunology;CD Markers

Function

TLR2, recognizes bacterial lipoproteins and endogenous alarmins, triggering NF-κB and cytokine production. Tomaralimab’s blockade of TLR2 aims to reduce sterile inflammation and tissue damage in conditions where aberrant TLR2 activation drives pathology. Its IgG4 isotype minimizes Fc-mediated effector functions, focusing on specific pathway inhibition to potentially avoid broad immunosuppression.

Additional Articles 1

Pathogen-sensor-TLR2

Additional Articles 2

Related Products

Anti-Human CD274/PDL1/B7H1 Antibody (22C3)

Catalog: 

RA0740

Target：

CD274/PDL1/B7H1

Isotype：

IgG - kappa

Applications：

ELISA;FC;Functional Assays;IF

Reactivities：

Human
Bempikibart (Biosimilar Reference Antibody) (IL7R)

Catalog: 

RA0740

Target：

IL7R/CD127

Isotype：

IgG1 - kappa

Applications：

ELISA;FC;Functional Assays;IF

Reactivities：

Human
Maftivimab (Biosimilar Reference Antibody) (Zaire Ebolavirus Glycoprotein)

Catalog: 

RA0740

Target：

Zaire Ebolaviru...

Isotype：

IgG1 - kappa

Applications：

Functional Assays

Reactivities：

Virus
Lusvertikimab (Biosimilar Reference Antibody) (IL7R)

Catalog: 

RA0740

Target：

IL7R/CD127

Isotype：

IgG4 - kappa

Applications：

ELISA;FC;Functional Assays;IF

Reactivities：

Human
Odesivimab (Biosimilar Reference Antibody) (Zaire Ebolavirus Glycoprotein)

Catalog: 

RA0740

Target：

Zaire Ebolaviru...

Isotype：

IgG1 - kappa

Applications：

Functional Assays

Reactivities：

Virus
Porgaviximab (Biosimilar Reference Antibody) (Zaire Ebolavirus Glycoprotein)

Catalog: 

RA0740

Target：

Zaire Ebolaviru...

Isotype：

IgG1 - kappa

Applications：

Functional Assays

Reactivities：

Virus
Enokizumab (Biosimilar Reference Antibody) (IL9)

Catalog: 

RA0740

Target：

IL9

Isotype：

IgG1 - kappa

Applications：

ELISA;FC;Functional Assays;IF

Reactivities：

Human
Bapotulimab (Biosimilar Reference Antibody) (ILDR2)

Catalog: 

RA0740

Target：

ILDR2

Isotype：

IgG2 - kappa

Applications：

ELISA;FC;Functional Assays;IF

Reactivities：

Human
Atoltivimab (Biosimilar Reference Antibody) (Zaire Ebolavirus Glycoprotein)

Catalog: 

RA0740

Target：

Zaire Ebolaviru...

Isotype：

IgG1 - kappa

Applications：

Functional Assays

Reactivities：

Virus
Tocilizumab (Biosimilar Reference Antibody) (IL6R)

Catalog: 

RA0740

Target：

IL6R/CD126

Isotype：

IgG1 - kappa

Applications：

ELISA;FC;Functional Assays;IF

Reactivities：

Human

Contact Us

Send your request

Talk to us 

Get a quotation, discuss your requirement, receive advises from our antibody experts without obligation.