Varisacumab (Biosimilar Reference Antibody) (VEGFA)
Varisacumab (Biosimilar Reference Antibody) (VEGFA)-RA0812-Oursmab determined by SDS-PAGE. The purity of the protein is greater than 98%.
Varisacumab (Biosimilar Reference Antibody) (VEGFA)

Catalog: 

RA0812

Target

VEGFA

Isotype

IgG1 - kappa

Applications

ELISA;FC;Functional Assays;IF

Reactivities

Human

Size (＄)：

100 μg-50;1 mg-210;5 mg-500;10 mg-800;25 mg-1750;50 mg-3000;100 mg-4600

Data Sheet

Material Safety Data Sheet

Certificate of Analysis

Product Description

Varisacumab is a recombinant human IgG1 kappa monoclonal antibody targeting vascular endothelial growth factor A (VEGFA), a key cytokine that drives angiogenesis and vascular permeability. It binds to VEGFA to block its interaction with VEGF receptors (VEGFR-1 and VEGFR-2), thereby inhibiting pathological blood vessel formation and leakage. It is being developed for the treatment of neovascular age-related macular degeneration (nAMD) and other retinal vascular diseases.

Synonyms

GNR-011, r84, AT-001

CAS

1610010-60-0

Isotype

IgG1 - kappa

Host

Genetically human

Target

VEGFA

Reactivity

Human

Expression System

CHO

Applications

ELISA, FC, Functional Assays, IF; Recommended dilution: FC, IF:1:200

Purity

>98% by SDS-PAGE

Concentration

Bottled at the concentration indicated on the vial.

Buffer

0.01M PBS, pH 7.4, contains no stabilizers or preservatives.

Endotoxin

<1.0 EU/mg as determined by LAL method

Conjugation

Non-conjugated

Formulation

Liquid or Lyophilized powder Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Storage

store at -20°C or -80°C. Avoid repeated freeze.

Type

Antibody

Purposes

For research use only

References 1

Johanna Breuer, et al. VLA-2 blockade in vivo by vatelizumab induces CD4+FoxP3+ regulatory T cells. Int Immunol. 2019 May 21;31(6):407-412.

References 2

References 3

References 4

References 5

Product Citations 1

Product Citations 2

https://pubmed.ncbi.nlm.nih.gov/30783682/
https://www.oursmab.com/News/The-angiogenin-VEGFA.html

Target Description

Synonyms

vascular endothelial growth factor A, VEGF-A, VEGF

Biology Area

Ophthalmology;Cancer Biology

Function

Vascular endothelial growth factor-A (VEGF-A), a key signaling protein that promotes the growth of abnormal, leaky blood vessels in the eye. These vessels are responsible for vision loss in conditions like wet AMD. As a VEGF inhibitor, Brolucizumab functions

Additional Articles 1

The-angiogenin-VEGFA

Additional Articles 2

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